Evidence map›Paper›PMID 38609439›Full record

ArticleCommunications biology2024

Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition.

Kelli R Goggans, Olga V Belyaeva, Alla V Klyuyeva, Jacob Studdard, Aja Slay, Regina B Newman, Christine A VanBuren, Helen B Everts, Natalia Y Kedishvili

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kelli R GoggansDepartment of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-7008-7506
Olga V BelyaevaDepartment of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Alla V KlyuyevaDepartment of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jacob StuddardDepartment of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Aja SlayDepartment of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Regina B NewmanDepartment of Nutrition and Food Sciences, Texas Woman's University, Denton, TX, USA.
Christine A VanBurenDepartment of Nutrition and Food Sciences, Texas Woman's University, Denton, TX, USA.
Helen B EvertsDepartment of Nutrition and Food Sciences, Texas Woman's University, Denton, TX, USA. heverts@twu.edu.ORCID 0000-0001-7406-2093
Natalia Y KedishviliDepartment of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. nkedishvili@uab.edu.ORCID 0000-0001-6917-4891
University of Alabama at Birmingham · USTexas Woman's University · US

Funding

Short-Chain Dehydrogenases in Retinol/Sterol MetabolismR01AR076924 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEDISHVILI, NATALIA Y · 2020 to 2024
$2.2M
NIAMS NIH HHS R01 AR076924
6 · The paper itself

Abstract

The hair follicle (HF) is a self-renewing adult miniorgan that undergoes drastic metabolic and morphological changes during precisely timed cyclic organogenesis. The HF cycle is known to be regulated by steroid hormones, growth factors and circadian clock genes. Recent data also suggest a role for a vitamin A derivative, all-trans-retinoic acid (ATRA), the activating ligand of transcription factors, retinoic acid receptors, in the regulation of the HF cycle. Here we demonstrate that ATRA signaling cycles during HF regeneration and this pattern is disrupted by genetic deletion of epidermal retinol dehydrogenases 2 (RDHE2, SDR16C5) and RDHE2-similar (RDHE2S, SDR16C6) that catalyze the rate-limiting step in ATRA biosynthesis. Deletion of RDHEs results in accelerated anagen to catagen and telogen to anagen transitions, altered HF composition, reduced levels of HF stem cell markers, and dysregulated circadian clock gene expression, suggesting a broad role of RDHEs in coordinating multiple signaling pathways.

Indexed as

EpidermisVitamin AAdultCatalysisHairHumansStem CellsTretinoinTretinoinVitamin A

Identifiers

PMID38609439
PMCPMC11014975
OpenAlexW4394766631

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.