Evidence map›Paper›PMID 38609177›Full record

ArticleJournal of medical genetics2024

Pathogenic variant detection rate varies considerably in male breast cancer families and sporadic cases: minimal additional contribution beyond

D Gareth Evans, George J Burghel, Sacha J Howell, Sarah Pugh, Claire Forde, Anthony Howell, Fiona Lalloo, Emma Roisin Woodward

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Case Report: A combination ofFrontiers in oncology · 2026
    Article
  2. Article
  3. Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

D Gareth EvansGenomic Medicine, MAHSC, Manchester, UK gareth.d.evans@manchester.ac.uk.ORCID 0000-0002-8482-5784
George J BurghelGenomic Diagnostic Laboratory, Manchester University NHS Foundation Trust, Manchester, UK.ORCID 0000-0001-9360-8194
Sacha J HowellWythenshawe Hospital Manchester Universities Foundation Trust, Wythenshawe, UK.
Sarah PughManchester University Hospitals NHS Foundation Trust, Manchester, UK.
Claire FordeClinical Genetics Service, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.ORCID 0000-0001-8035-4471
Anthony HowellPrevent Breast Cancer Centre, Manchester, UK.
Fiona LallooClinical Genetics Service, Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Emma Roisin WoodwardManchester Centre for Genomic Medicine, Central Manchester NHS Foundation Trust, Manchester, UK.
Manchester Academic Health Science Centre · GBManchester University · USManchester University NHS Foundation Trust · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMale breast cancer (MBC) affects around 1 in 1000 men and is known to have a higher underlying component of high and moderate risk gene pathogenic variants (PVs) than female breast cancer, particularly in

methodsWe reviewed germline testing in 204 families including at least one MBC for

resultsIn the 204 families,

Indexed as

BRCA1 ProteinBRCA2 ProteinBreast Neoplasms, MaleCheckpoint Kinase 2Germ-Line MutationAdultAgedBreast NeoplasmsFemaleGenetic Predisposition to DiseaseGenetic TestingHumansMaleMiddle AgedPedigreeProstatic NeoplasmsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanCheckpoint Kinase 2CHEK2 protein, humanGenetic CounselingGenetic TestingHuman GeneticsMen's HealthMolecular Epidemiology

Identifiers

PMID38609177
PMCPMC11420751
OpenAlexW4394745361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.