Evidence map›Paper›PMID 38609097›Full record

Observational studyThe European respiratory journal2024

Airway clearance management in people with bronchiectasis: data from the European Bronchiectasis Registry (EMBARC).

Arietta Spinou, Beatriz Hererro-Cortina, Stefano Aliberti, Pieter C Goeminne, Eva Polverino, Katerina Dimakou, Charles S Haworth, Michael R Loebinger, Anthony De Soyza, Montserrat Vendrell and 29 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract readObservational StudyMulticenter Study
In one paragraph

Observational study in The European respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06801327 (Comparison Between Different Respiratory Physiotherapy Techniques in Patients With Bronchiectasis. Conventional Therapy Versus Simeox), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06801327 narecruitingnot on this map

Comparison Between Different Respiratory Physiotherapy Techniques in Patients With Bronchiectasis. Conventional Therapy Versus Simeox: a Single-center, Randomized, Controlled, Cross-over Study

TypeinterventionalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2024 to 2026Enrolled40ConditionsBronchiectasis AdultArmsSimeox
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Guideline
  2. Mucoactive agents in bronchiectasis: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  3. Guideline
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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  13. Article
  14. Review
  15. Review
  16. Review
  17. Whole-genome and pan-genome analyses reveal genomic differences among nontypeableFrontiers in cellular and infection microbiology · 2026
    Article
  18. Greater disease severity in adults with paediatric-onsetThe European respiratory journal · 2026
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors at 20 institutions in 18 countries.

Arietta SpinouPopulation Health Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0002-3442-4739
Beatriz Hererro-CortinaUniversidad San Jorge, Zaragoza, Spain.
Stefano AlibertiIRCCS Humanitas Research Hospital, Respiratory Unit, Milan, Italy.ORCID 0000-0002-0090-4531
Pieter C GoeminneDepartment of Respiratory Disease, AZ Nikolaas, Sint-Niklaas, Belgium.
Eva PolverinoPneumology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, CIBERES, Barcelona, Spain.
Katerina Dimakou5th Respiratory Department and Bronchiectasis Unit, "SOTIRIA" General Hospital of Chest Diseases Medical Practice, Athens, Greece.
Charles S HaworthCambridge Centre for Lung Infection, Royal Papworth Hospital and University of Cambridge, Cambridge, UK.
Michael R LoebingerRoyal Brompton and Harefield Hospitals and National Heart and Lung Institute, Imperial College London, London, UK.
Anthony De SoyzaPopulation and Health Science Institute, Newcastle University and NIHR Biomedical Research Centre for Ageing, Freeman Hospital, Newcastle, UK.ORCID 0000-0002-8566-0344
Montserrat VendrellDepartment of Pulmonology, Dr Trueta University Hospital, Girona Biomedical Research Institute (IDIBGI), University of Girona, Girona, Spain.
Pierre Regis BurgelDepartment of Respiratory Medicine and French Cystic Fibrosis National Reference Center, Hôpital Cochin, AP-HP, Paris, France.ORCID 0000-0003-0903-9828
Melissa McDonnellDepartment of Respiratory Medicine, Galway University Hospital, Galway, Ireland.ORCID 0000-0002-5721-5710
Sivagurunathan SutharsanDepartment of Pulmonary Medicine, University Hospital Essen - Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Essen, Germany.
Sabina ŠkrgatUniversity Medical Centre Ljubljana, Department of Pulmonary Diseases and Allergy, Ljubljana, Slovenia.
Luiz Maiz-CarroChronic Bronchial Infection Unit, Pneumology Service, Ramón y Cajal Hospital, Alcalá de Henares University, Madrid, Spain.
Oriol SibilaServicio de Neumología, Instituto Clínico de Respiratorio, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain.
Daiana StolzDepartment of Pneumology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Paula KauppiHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Apostolos BossiosDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-0494-2690
Adam T HillRoyal Infirmary of Edinburgh, Department of Respiratory Medicine, Edinburgh, UK.
Ian CliftonLeeds Teaching Hospitals NHS Trust, Leeds, UK.
Megan L CrichtonDivision of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Paul WalkerLiverpool University Hospitals Foundation NHS Trust, Liverpool, UK.
Rosario MenendezPneumology Department, Hospital Universitario y Politécnico La Fe-Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
Sermin BorekciIstanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Pulmonology Diseases, Istanbul, Turkey.
Dusanka ObradovicFaculty of Medicine Novi Sad, University of Novi Sad, Novi Sad, Serbia.
Adam NowinskiDepartment of Epidemiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Adelina AmorimPulmonology Department, Centro Hospitalar Universitário S. João, Porto, Portugal.
Antoni TorresDepartment of Pulmonology Hospital Clinic of Barcelona, Spain University of Barcelona, CIBERES, IDIBAPS, ICREA Barcelona, Barcelona, Spain.ORCID 0000-0002-8643-2167
Natalie LorentDepartment of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-2653-5885
Tobias WelteDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-9947-7356
Francesco BlasiDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Mateja Jankovic MakekUniversity of Zagreb School of Medicine and University Hospital Centre Zagreb, Zagreb, Croatia.ORCID 0000-0002-0171-764X
Michal ShteinbergPulmonology Institute and CF Center, Carmel Medical Center, Haifa, Israel.ORCID 0000-0002-0432-3398
Wim BoersmaDepartment of Pulmonary Diseases, Northwest Clinics, Alkmaar, The Netherlands.
J Stuart ElbornFaculty of Medicine, Health and Life Sciences, Queen's University, Belfast, UK.
James D ChalmersDivision of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK j.chalmers@dundee.ac.uk.
Felix C RingshausenDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-9084-4968
EMBARC Registry Collaborators
Medizinische Hochschule Hannover · DEUniversity of Dundee · GBEdinburgh Royal Infirmary · GBFreeman Hospital · GBHarefield Hospital · GBHospital Clínic de Barcelona · ESHumanitas University · ITInserm · FRInstituto de Investigación Sanitaria La Fe · ESInstituto de Salud Carlos III · ESIstanbul University-Cerrahpaşa · TRKarolinska University Hospital · SEKing's College London · GBKU Leuven · BELeeds Teaching Hospitals NHS Trust · GBNorthwest Hospital · USQueen's University Belfast · GBRuhrlandklinik · DESotiria General Hospital · GRTechnion – Israel Institute of Technology · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInternational guidelines recommend airway clearance management as one of the important pillars of bronchiectasis treatment. However, the extent to which airway clearance is used for people with bronchiectasis in Europe is unclear. The aim of the study was to identify the use of airway clearance management in patients with bronchiectasis across different countries and factors influencing airway clearance use.

methodsThis was a prospective observational study using data from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) Registry between January 2015 and April 2022. Prespecified options for airway clearance management were recorded, including airway clearance techniques, devices and use of mucoactive drugs.

results16 723 people with bronchiectasis from 28 countries were included in the study. The mean age was 67 years (interquartile range 57-74 years, range 18-100 years) and 61% were female. 72% of the participants reported daily sputum expectoration and 52% (95% CI 51-53%) of all participants reported using regular airway clearance management. Active cycle of breathing technique was used by 28% of the participants and airway clearance devices by 16% of participants. The frequency of airway clearance management and techniques used varied significantly between different countries. Participants who used airway clearance management had greater disease severity and worse symptoms, including a higher daily sputum volume, compared to those who did not use it regularly. Mucoactive drugs were also more likely to be used in participants with more severe disease. Access to specialist respiratory physiotherapy was low throughout Europe, but particularly low in Eastern Europe.

conclusionsOnly a half of people with bronchiectasis in Europe use airway clearance management. Use of and access to devices, mucoactive drugs and specialist chest physiotherapy appears to be limited in many European countries.

Indexed as

BronchiectasisRegistriesAdolescentAdultAgedAged, 80 and overAirway ManagementEuropeExpectorantsFemaleHumansMaleMiddle AgedProspective StudiesRespiratory TherapyYoung AdultExpectorants

Identifiers

PMID38609097
PMCPMC11154755
OpenAlexW4394766043

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.