Evidence map›Paper›PMID 38608928›Full record

ReviewJournal of molecular and cellular cardiology2024

Unraveling the Gordian knot of coronary pressure-flow autoregulation.

Johnathan D Tune, Cooper M Warne, Salman I Essajee, Selina M Tucker, C Alberto Figueroa, Gregory M Dick, Daniel A Beard

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Johnathan D TuneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, USA. Electronic address: johnathan.tune@unthsc.edu.
Cooper M WarneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, USA.
Salman I EssajeeDepartment of Physiology and Anatomy, University of North Texas Health Science Center, USA.
Selina M TuckerDepartment of Physiology and Anatomy, University of North Texas Health Science Center, USA.
C Alberto FigueroaSection of Vascular Surgery, Department of Surgery, University of Michigan, USA; Department of Biomedical Engineering, University of Michigan, USA.
Gregory M DickDepartment of Physiology and Anatomy, University of North Texas Health Science Center, USA.
Daniel A BeardDepartment of Molecular and Integrative Physiology, University of Michigan, USA.

Funding

Disentangling the Mechanisms of Coronary Blood Flow Regulation through Multi-scale ModelingR01HL158723 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A, FIGUEROA, CARLOS ALBERTO · 2022 to 2025
$2.7M
American Heart Association-American Stroke Association 23PRE1012811NHLBI NIH HHS R01 HL158723NIH HHS R01 HL158723
6 · The paper itself

Abstract

The coronary circulation has the inherent ability to maintain myocardial perfusion constant over a wide range of perfusion pressures. The phenomenon of pressure-flow autoregulation is crucial in response to flow-limiting atherosclerotic lesions which diminish coronary driving pressure and increase risk of myocardial ischemia and infarction. Despite well over half a century of devoted research, understanding of the mechanisms responsible for autoregulation remains one of the most fundamental and contested questions in the field today. The purpose of this review is to highlight current knowledge regarding the complex interrelationship between the pathways and mechanisms proposed to dictate the degree of coronary pressure-flow autoregulation. Our group recently likened the intertwined nature of the essential determinants of coronary flow control to the symbolically unsolvable "Gordian knot". To further efforts to unravel the autoregulatory "knot", we consider recent challenges to the local metabolic and myogenic hypotheses and the complicated dynamic structural and functional heterogeneity unique to the heart and coronary circulation. Additional consideration is given to interrogation of putative mediators, role of K

Indexed as

Coronary CirculationHomeostasisAnimalsBlood PressureCoronary VesselsHemodynamicsHumansCoronary blood flowHeterogeneityLocal metabolic controlMyogenic response

Identifiers

PMID38608928
PMCPMC12210212

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.