Evidence map›Paper›PMID 38608551›Full record

ArticlePediatric neurology2024

The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome.

Marisela E Dy-Hollins, Samuel J Carr, Angela Essa, Lisa Osiecki, Daniel T Lackland, Jenifer H Voeks, Nicte I Mejia, Nutan Sharma, Cathy L Budman, Danielle C Cath and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Pediatric neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 3 countries.

Marisela E Dy-HollinsDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: mdyhollins@mgb.org.
Samuel J CarrDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Angela EssaDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Lisa OsieckiDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Daniel T LacklandDepartment of Neurology, Medical University of South Carolina, Charleston, South Carolina.
Jenifer H VoeksDepartment of Neurology, Medical University of South Carolina, Charleston, South Carolina.
Nicte I MejiaDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Nutan SharmaDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Cathy L BudmanDepartment of Psychiatry, Northwell, New York, New York.
Danielle C CathDepartment of Psychiatry, University Medical Center Groningen, Rijks Universiteit Groningen, and Drenthe Mental Health Institute, Groningen, Netherlands.
Marco A GradosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Robert A KingYale Child Study Center, Yale School of Medicine, New Haven, Connecticut.
Gholson J LyonGeorge A. Jervis Clinic and Institute for Basic Research in Developmental Disabilities, Staten Island, New York.
Guy A RouleauDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University Health Center, Montreal, Canada.
Paul SandorDepartment of Psychiatry, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Harvey S SingerDepartments of Pediatrics and Neurology, Johns Hopkins Hospital, Kennedy Krieger Institute, Baltimore, Maryland.
Lori B ChibnikDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Carol A MathewsDepartment of Psychiatry, Center for OCD, Anxiety and Related Disorders, University of Florida, Gainsville, Florida.
Jeremiah M ScharfDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Harvard University · USMedical University of South Carolina · USJohns Hopkins University · USKennedy Krieger Institute · USMontreal Neurological Institute and Hospital · CANew York State Office for People With Developmental Disabilities · USNorthwell Health · USUniversity Health Network · CAUniversity Medical Center Groningen · NLUniversity of Florida · USYale University · US

Funding

Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
Integrating Common and Rare Variation to Discover Genes Associated with Tourette SyndromeR01NS102371 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATHEWS, CAROL A, OPHOFF, ROEL A · 2018 to 2022
$7.4M
TorsinA as a key link in receptor-mediated signalingP01NS087997 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI STANDAERT, DAVID G. · 2015 to 2019
$6.4M
Large-Scale Collaborative Genetic and Epigenetic Studies of Tourette SyndromeR01NS105746 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATHEWS, CAROL A, PASCHOU, PERISTERA · 2019 to 2023
$3.1M
Natural history study of x-linked Dystonia ParkinsonismR21NS118541 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SHARMA, NUTAN · 2020 to 2021
$420k
NINDS NIH HHS K12 NS098482NINDS NIH HHS P01 NS087997NINDS NIH HHS R01 NS102371NINDS NIH HHS R01 NS105746NINDS NIH HHS R21 NS118541
6 · The paper itself

Abstract

backgroundTo examine the association between race, ethnicity, and parental educational attainment on tic-related outcomes among Tourette Syndrome (TS) participants in the Tourette Association of America International Consortium for Genetics (TAAICG) database.

methods723 participants in the TAAICG dataset aged ≤21 years were included. The relationships between tic-related outcomes and race and ethnicity were examined using linear and logistic regressions. Parametric and nonparametric tests were performed to examine the association between parental educational attainment and tic-related outcomes.

resultsRace and ethnicity were collapsed as non-Hispanic white (N=566, 88.0%) versus Other (N=77, 12.0%). Tic symptom onset was earlier by 1.1 years (P < 0.0001) and TS diagnosis age was earlier by 0.9 years (P = 0.0045) in the Other group (versus non-Hispanic white). Sex and parental education as covariates did not contribute to the differences observed in TS diagnosis age. There were no significant group differences observed across the tic-related outcomes in parental education variable.

conclusionsOur study was limited by the low number of nonwhite or Hispanic individuals in the cohort. Racial and ethnic minoritized groups experienced an earlier age of TS diagnosis than non-Hispanic white individuals. Tic severity did not differ between the two groups, and parental educational attainment did not affect tic-related outcomes. There remain significant disparities and gaps in knowledge regarding TS and associated comorbid conditions. Our study suggests the need for more proactive steps to engage individuals with tic disorders from all racial and ethnic minoritized groups to participate in research studies.

Indexed as

Social Determinants of HealthTourette SyndromeAdolescentAdultChildChild, PreschoolEducational StatusEthnicityFemaleHumansMaleParentsRacial GroupsUnited StatesWhiteYoung AdultDisparitiesEthnicityRaceSocial determinants of healthTourette Syndrome

Identifiers

PMID38608551
PMCPMC11132913
OpenAlexW4392388927

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.