Evidence map›Paper›PMID 38608295›Full record

ReviewAnnual review of analytical chemistry (Palo Alto, Calif.)2024

Integrated In-Plane Nanofluidic Devices for Resistive-Pulse Sensing.

Tanner W Young, Michael P Kappler, Ethan D Call, Quintin J Brown, Stephen C Jacobson

Abstract readReview
In one paragraph

Review in Annual review of analytical chemistry (Palo Alto, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tanner W YoungDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA; email: jacobson@iu.edu.
Michael P KapplerDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA; email: jacobson@iu.edu.
Ethan D CallDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA; email: jacobson@iu.edu.
Quintin J BrownDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA; email: jacobson@iu.edu.
Stephen C JacobsonDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA; email: jacobson@iu.edu.

Funding

Single-Particle Analysis of Virus Capsids, Bacteria, and Extracellular VesiclesR35GM141922 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Stephen C Jacobson · 2021 to 2026
$3.5M
NIGMS NIH HHS R35 GM141922
6 · The paper itself

Abstract

Single-particle (or digital) measurements enhance sensitivity (10- to 100-fold improvement) and uncover heterogeneity within a population (one event in 100 to 10,000). Many biological systems are significantly influenced by rare or infrequent events, and determining what species is present, in what quantity, and the role of that species is critically important to unraveling many questions. To develop these measurement systems, resistive-pulse sensing is used as a label-free, single-particle detection technique and can be combined with a range of functional elements, e.g., mixers, reactors, filters, separators, and pores. Virtually, any two-dimensional layout of the micro- and nanofluidic conduits can be envisioned, designed, and fabricated in the plane of the device. Multiple nanopores in series lead to higher-precision measurements of particle size, shape, and charge, and reactions coupled directly with the particle-size measurements improve temporal response. Moreover, other detection techniques, e.g., fluorescence, are highly compatible with the in-plane format. These integrated in-plane nanofluidic devices expand the toolbox of what is possible with single-particle measurements.

Indexed as

biomoleculesin-planeintegrated devicesnanofabricationnanofluidicsresistive-pulse sensing

Identifiers

PMID38608295
PMCPMC11636403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.