Evidence map›Paper›PMID 38608030›Full record

ArticleScience advances2024

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation.

Melad Henis, Tabitha Rücker, Robin Scharrenberg, Melanie Richter, Lucas Baltussen, Shuai Hong, Durga Praveen Meka, Birgit Schwanke, Nagammal Neelagandan, Danie Daaboul and 10 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. A Hypothesis: Metabolic Contributions to 16p11.2 Deletion Syndrome.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  5. Expanding the phenotype and genotype spectrum of TAOK1 neurodevelopmental disorder and delineating TAOK2 neurodevelopmental disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2025
    Article
  6. Article
  7. The pleiotropic spectrum of proximal 16p11.2 CNVs.American journal of human genetics · 2024
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 6 countries.

Melad HenisCenter for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0002-2884-8375
Tabitha RückerCenter for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Robin ScharrenbergCenter for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0001-7825-894X
Melanie RichterCenter for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0003-0575-9625
Lucas BaltussenVIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0001-9742-6857
Shuai HongCenter for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0009-0003-6159-5386
Durga Praveen MekaCenter for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0003-1058-9827
Birgit SchwankeCenter for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Nagammal NeelagandanNeuronal Translational Control Group, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany.ORCID 0000-0002-8530-1587
Danie DaaboulVIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0001-8542-650X
Nadeem MurtazaKrembil Research Institute, Donald K. Johnson Eye Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.ORCID 0000-0003-1290-8924
Christoph KrispInstitute for Clinical Chemistry and Laboratory Medicine, Mass Spectrometric Proteomics Group, Campus Forschung, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.
Sönke HarderInstitute for Clinical Chemistry and Laboratory Medicine, Mass Spectrometric Proteomics Group, Campus Forschung, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.ORCID 0000-0002-6352-4771
Hartmut SchlüterInstitute for Clinical Chemistry and Laboratory Medicine, Mass Spectrometric Proteomics Group, Campus Forschung, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.ORCID 0000-0002-9358-7036
Matthias KneusselInstitute of Neurogenetics, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany.ORCID 0000-0003-4900-366X
Irm Hermans-BorgmeyerTransgenic Service Group, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany.
Joris de WitVIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0003-1120-1089
Karun K SinghKrembil Research Institute, Donald K. Johnson Eye Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.
Kent E DuncanNeuronal Translational Control Group, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany.ORCID 0000-0003-4290-2670
Froylan Calderón de AndaCenter for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0003-2743-7774
Universität Hamburg · DEAllen Institute for Brain Science · USUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the

Indexed as

Autism Spectrum DisorderAutistic DisorderUrsidaeAnimalsBiological AssayMicePeptide Elongation Factor 2PhosphorylationPeptide Elongation Factor 2

Identifiers

PMID38608030
PMCPMC11014455
OpenAlexW4394743670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.