Evidence map›Paper›PMID 38608016›Full record

ArticleScience advances2024

Mechanisms used for cDNA synthesis and site-specific integration of RNA into DNA genomes by a reverse transcriptase-Cas1 fusion protein.

Georg Mohr, Jun Yao, Seung Kuk Park, Laura Markham, Alan M Lambowitz

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Georg MohrDepartments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-6411-0685
Jun YaoDepartments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-1232-1587
Seung Kuk ParkDepartments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0003-3795-1347
Laura MarkhamDepartments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0009-0006-7339-986X
Alan M LambowitzDepartments of Molecular Biosciences and Oncology, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-6036-2423
The University of Texas at Austin · US

Funding

Group II Intron and Related Reverse TranscriptasesR35GM136216 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ALAN M. LAMBOWITZ · 2020 to 2026
$6.0M
NIGMS NIH HHS R35 GM136216
6 · The paper itself

Abstract

Reverse transcriptase-Cas1 (RT-Cas1) fusion proteins found in some CRISPR systems enable spacer acquisition from both RNA and DNA, but the mechanism of RNA spacer acquisition has remained unclear. Here, we found that

Indexed as

RNARNA-Directed DNA PolymeraseDNADNA, ComplementaryDNA, Single-StrandedDNADNA, ComplementaryDNA, Single-StrandedRNARNA-Directed DNA Polymerase

Identifiers

PMID38608016
PMCPMC11014452
OpenAlexW4394769609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.