Evidence map›Paper›PMID 38608012›Full record

ArticleScience advances2024

Smaug regulates germ plasm assembly and primordial germ cell number in Drosophila embryos.

Najeeb U Siddiqui, Angelo Karaiskakis, Aaron L Goldman, Whitby V I Eagle, Timothy C H Low, Hua Luo, Craig A Smibert, Elizabeth R Gavis, Howard D Lipshitz

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Najeeb U SiddiquiDepartment of Molecular Genetics, University of Toronto, 661 University Avenue, Toronto, ON M5G 1M1, Canada.ORCID 0009-0006-6500-9630
Angelo KaraiskakisDepartment of Molecular Genetics, University of Toronto, 661 University Avenue, Toronto, ON M5G 1M1, Canada.ORCID 0000-0001-9033-2524
Aaron L GoldmanDepartment of Molecular Genetics, University of Toronto, 661 University Avenue, Toronto, ON M5G 1M1, Canada.ORCID 0000-0002-6495-8627
Whitby V I EagleDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0003-4762-5940
Timothy C H LowDepartment of Molecular Genetics, University of Toronto, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Hua LuoDepartment of Molecular Genetics, University of Toronto, 661 University Avenue, Toronto, ON M5G 1M1, Canada.ORCID 0009-0005-0914-6086
Craig A SmibertDepartment of Molecular Genetics, University of Toronto, 661 University Avenue, Toronto, ON M5G 1M1, Canada.ORCID 0000-0001-6375-8669
Elizabeth R GavisDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0003-0251-0760
Howard D LipshitzDepartment of Molecular Genetics, University of Toronto, 661 University Avenue, Toronto, ON M5G 1M1, Canada.ORCID 0000-0002-7372-4419
University of Toronto · CAPrinceton University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Mechanisms of mRNA localization and translational control in Drosophila developmentR35GM126967 · NIGMS · PRINCETON UNIVERSITY · PI ELIZABETH R GAVIS · 2018 to 2026
$5.9M
Mechanism of RNA Localization in Drosophila DevelopmentR01GM067758 · NIGMS · PRINCETON UNIVERSITY · PI GAVIS, ELIZABETH R · 2004 to 2017
$5.3M
NIGMS NIH HHS R01 GM067758NIGMS NIH HHS R35 GM126967NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

During Drosophila oogenesis, the Oskar (OSK) RNA binding protein (RBP) determines the amount of germ plasm that assembles at the posterior pole of the oocyte. Here, we identify mechanisms that subsequently regulate germ plasm assembly in the early embryo. We show that the Smaug (SMG) RBP is transported into the germ plasm of the early embryo where it accumulates in the germ granules. SMG binds to and represses translation of the

Indexed as

DrosophilaLizardsAnimalsCell CountCytoplasmGerm CellsRNA, MessengerRNA, Messenger

Identifiers

PMID38608012
PMCPMC11014450
OpenAlexW4394769654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.