ArticlePLoS biology2024
Genome-wide association studies have problems due to confounding: Are family-based designs the answer?
Article in PLoS biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk.Molecular biology and evolution · 2026Article
- Article
- Beyond years of schooling: Genetic associations across educational milestones in two Norwegian cohorts.PLoS genetics · 2026Article
- Within-sibling attenuation of polygenic risk score accuracy: investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank.Human genetics · 2026Article
- Gene expression profiling by RNA-sequencing reveals regulators of intramuscular fat in Black Slavonian pigs.Scientific reports · 2026Article
- Estimating returns to education using the genetic lottery.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Within- and between-family genetic effects on educational achievement vary across countries and ages.Molecular psychiatry · 2026Article
- Dissecting the Predictive Accuracy of Polygenic Indexes for Behavioral Phenotypes Across Genetic Ancestries.bioRxiv : the preprint server for biology · 2026Article
- Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene-environment interplay with family conflict and parental acceptance.Development and psychopathology · 2025Article
- Family-GWAS reveals effects of environment and mating on genetic associations.medRxiv : the preprint server for health sciences · 2025Article
- Dissecting the Predictive Accuracy of Polygenic Indexes for Behavioral Phenotypes Across Genetic Ancestries.Research square · 2025Article
- Genotypic and socioeconomic risks for depressive symptoms in two U.S. cohorts spanning early to older adulthood.Journal of psychopathology and clinical science · 2025Article
- Family-based genome-wide association study designs for increased power and robustness.Nature genetics · 2025Article
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Abstract
Genome-wide association studies (GWASs) can be affected by confounding. Family-based GWAS uses random, within-family genetic variation to avoid this. A study in PLOS Biology details how different sources of confounding affect GWAS and whether family-based designs offer a solution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.