Evidence map›Paper›PMID 38607933›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Posttranscriptional regulation of

Kyung-Hee Kim, Eun Pyo Hong, Yukyeong Lee, Zachariah L McLean, Emanuela Elezi, Ramee Lee, Seung Kwak, Branduff McAllister, Thomas H Massey, Sergey Lobanov and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Emerging drivers of DNA repeat expansions.Biochemical Society transactions · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. MicroRNA Gets a Mighty Award.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 3 countries.

Kyung-Hee KimCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Eun Pyo HongCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Yukyeong LeeCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Zachariah L McLeanCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Emanuela EleziCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Ramee LeeCHDI Foundation, Princeton, NJ 08540.
Seung KwakCHDI Foundation, Princeton, NJ 08540.
Branduff McAllisterCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Thomas H MasseyCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
Sergey LobanovCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
Peter HolmansCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
Michael OrthUniversity Hospital of Old Age Psychiatry and Psychotherapy, Bern University, CH-3000 Bern 60, Switzerland.
Marc CiosiSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Darren G MoncktonSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.ORCID 0000-0002-8298-8264
Jeffrey D LongDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Diane LucenteCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Vanessa C WheelerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Marcy E MacDonaldCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
James F GusellaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Jong-Min LeeCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0001-5799-0787
Broad Institute · USHarvard University · USCardiff University · GBMassachusetts General Hospital · USCHDI Foundation · USUniversity of Glasgow · GBUniversity Hospital of Bern · CHUniversity of Iowa · US

Funding

Huntington's Disease Repeat Instability and PathogenesisR01NS049206 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VANESSA C WHEELER · 2005 to 2026
$10.0M
Disease-Modifying Genes in Huntington's DiseaseR01NS091161 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI JAMES F GUSELLA · 2015 to 2026
$7.2M
Genetic Mechanisms Controlling Resilience to Huntington's DiseaseR01NS125742 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUSELLA, JAMES F, KACZOROWSKI, CATHERINE COOK · 2022 to 2025
$4.1M
Therapeutic Potential of Base Editing Strategies to Convert CAG to CAA in Huntington's DiseaseR01NS119471 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JONG-MIN · 2021 to 2025
$2.6M
Genetic foundation for complete mutant allele-specific CRISPR in neurodegenerative diseasesR01NS105709 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JONG-MIN · 2018 to 2022
$2.4M
NINDS NIH HHS R01 NS049206NINDS NIH HHS R01 NS091161NINDS NIH HHS R01 NS105709NINDS NIH HHS R01 NS119471NINDS NIH HHS R01 NS125742
6 · The paper itself

Abstract

Many Mendelian disorders, such as Huntington's disease (HD) and spinocerebellar ataxias, arise from expansions of CAG trinucleotide repeats. Despite the clear genetic causes, additional genetic factors may influence the rate of those monogenic disorders. Notably, genome-wide association studies discovered somewhat expected modifiers, particularly mismatch repair genes involved in the CAG repeat instability, impacting age at onset of HD. Strikingly,

Indexed as

Huntington DiseaseMicroRNAs3' Untranslated RegionsEndodeoxyribonucleasesExodeoxyribonucleasesGenome-Wide Association StudyHumansMultifunctional Enzymes3' Untranslated RegionsEndodeoxyribonucleasesExodeoxyribonucleasesFAN1 protein, humanMicroRNAsMIRN124 microRNA, humanMultifunctional EnzymesFAN1genetic modifierHuntington’s diseasemiR-124-3prs3512

Identifiers

PMID38607933
PMCPMC11032436
OpenAlexW4394769358

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.