Evidence map›Paper›PMID 38607680›Full record

ArticleBiochemistry2024

Polyethylene Glycol Impacts Conformation and Dynamics of

Jessica Liebau, Bethany F Laatsch, Joshua Rusnak, Keegan Gunderson, Brianna Finke, Kassandra Bargender, Alex Narkiewicz-Jodko, Katelyn Weeks, Murphi T Williams, Irina Shulgina and 3 more

Abstract read
In one paragraph

Article in Biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Residue-level mapping of crowding effects on protein phase separation.Protein science : a publication of the Protein Society · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Preparing for successful protein crystallization experiments.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  13. Lab-scale production of postbiotic proteins fromFrontiers in microbiology · 2025
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jessica LiebauDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Bethany F LaatschDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Joshua RusnakDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Keegan GundersonDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Brianna FinkeDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Kassandra BargenderDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Alex Narkiewicz-JodkoDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Katelyn WeeksDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Murphi T WilliamsDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.
Irina ShulginaDepartment of Chemistry and Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, United States.
Karin Musier-ForsythDepartment of Chemistry and Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, United States.
Sudeep BhattacharyyaDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.ORCID 0000-0002-3960-1239
Sanchita HatiDepartment of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702, United States.

Funding

Translational quality control by tRNA-editing domainsR35GM141880 · NIGMS · OHIO STATE UNIVERSITY · PI Karin M Musier-Forsyth · 2021 to 2026
$2.9M
Exploring the Dynamics of Prolyl-tRNA Synthetases: Towards Developing a Screening Method for Species-Specific InhibitorsR15GM117510 · NIGMS · UNIVERSITY OF WISCONSIN EAU CLAIRE · PI BHATTACHARYAY, SUDEEP, HATI, SANCHITA · 2016 to 2023
$878k
NIGMS NIH HHS R15 GM117510NIGMS NIH HHS R35 GM141880
6 · The paper itself

Abstract

Polyethylene glycol (PEG) is a flexible, nontoxic polymer commonly used in biological and medical research, and it is generally regarded as biologically inert. PEG molecules of variable sizes are also used as crowding agents to mimic intracellular environments. A recent study with PEG crowders revealed decreased catalytic activity of

Indexed as

Amino Acyl-tRNA SynthetasesEscherichia coliMolecular Dynamics SimulationPolyethylene GlycolsProtein ConformationCatalytic DomainEscherichia coli ProteinsMicroscopy, Atomic ForceMolecular WeightAmino Acyl-tRNA SynthetasesEscherichia coli ProteinsPolyethylene Glycolsprolyl T RNA synthetase

Identifiers

PMID38607680
PMCPMC11223479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.