Evidence map›Paper›PMID 38607670›Full record

ArticleeLife2024

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states.

Junjun Yao, Shaoxing Dai, Ran Zhu, Ju Tan, Qiancheng Zhao, Yu Yin, Jiansen Sun, Xuewei Du, Longjiao Ge, Jianhua Xu and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Junjun Yao *State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID https://orcid.org/0000-0002-5190-4611
Shaoxing Dai *State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Ran Zhu *State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID https://orcid.org/0000-0003-0874-9369
Ju Tan *Department of Anatomy, National and Regional Engineering Laboratory of Tissue Engineering, State Key Laboratory of Trauma, Burn and Combined Injury, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, China.
Qiancheng ZhaoState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Yu YinState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Jiansen SunZhong-Zhi- Yi-Gu Research Institute, Chongqing, China.
Xuewei DuState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Longjiao GeState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Jianhua XuDepartment of Anatomy, National and Regional Engineering Laboratory of Tissue Engineering, State Key Laboratory of Trauma, Burn and Combined Injury, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, China.
Chunli HouDepartment of Anatomy, National and Regional Engineering Laboratory of Tissue Engineering, State Key Laboratory of Trauma, Burn and Combined Injury, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, China.
Nan LiState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID https://orcid.org/0000-0003-2111-4835
Jun LiYunnan Key Laboratory of Primate Biomedical Research, Kunming, China.
Weizhi JiState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Chuhong ZhuDepartment of Anatomy, National and Regional Engineering Laboratory of Tissue Engineering, State Key Laboratory of Trauma, Burn and Combined Injury, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, China.
Runrui ZhangState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID https://orcid.org/0000-0003-2871-0859
Tianqing LiState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID https://orcid.org/0000-0001-7453-0184
Kunming University of Science and Technology · CNArmy Medical University · CNYunnan Yingmao Biotechnology (China) · CN

Funding

Major Basic Research Project of Science and Technology of Yunnan 202001BC070001 and 202102AA100053National Key Research and Development Program of China 2022YFA1103100National Natural Science Foundation of China 32070864 and 32160153Natural Science Foundation of Yunnan Province 202101AT070287Natural Science Foundation of Yunnan Province 202105AD160008Natural Science Foundation of Yunnan Province 202207AA110003STI2030-Major Projects 2022ZD0207700The Key Research Project of Science and Technology of Yunnan YNWR-YLXZ-2020-015Xingdian Talent Support Program KKRD202273100
6 · The paper itself

Abstract

While accumulated publications support the existence of neurogenesis in the adult human hippocampus, the homeostasis and developmental potentials of neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas of the human hippocampus across neonatal, adult, aging, and injury, we dissected the molecular heterogeneity and transcriptional dynamics of human hippocampal NSCs under different contexts. We further identified new specific neurogenic lineage markers that overcome the lack of specificity found in some well-known markers. Based on developmental trajectory and molecular signatures, we found that a subset of NSCs exhibit quiescent properties after birth, and most NSCs become deep quiescence during aging. Furthermore, certain deep quiescent NSCs are reactivated following stroke injury. Together, our findings provide valuable insights into the development, aging, and reactivation of the human hippocampal NSCs, and help to explain why adult hippocampal neurogenesis is infrequently observed in humans.

Indexed as

AgingNeural Stem CellsAdultCell DivisionHippocampusHomeostasisHumansInfant, Newbornagingdevelopmenthumanhuman hippocampusinjurymolecular heterogeneityneural stem cellneuroscienceregenerative medicinestem cells

Identifiers

PMID38607670
PMCPMC11014727
OpenAlexW4385719309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.