Evidence map›Paper›PMID 38607584›Full record

ArticleProbiotics and antimicrobial proteins2025

Preventive and Therapeutic Potential of Streptococcus cristatus CA119 in Experimental Periodontitis in Rats.

Dongyu Zhao, Ming-Han Li, Tianxu Pan, Jialin Guo, Junyi Li, Chunwei Shi, Nan Wang, Haibin Huang, Chunfeng Wang, Guilian Yang

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dongyu Zhao *College of Veterinary Medicine, Jilin Agricultural University, Changchun, China.
Ming-Han Li *College of Veterinary Medicine, Jilin Agricultural University, Changchun, China.
Tianxu PanCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, China.
Jialin GuoCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, China.
Junyi LiCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, China.
Chunwei ShiCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, China.
Nan WangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, China.
Haibin HuangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, China.
Chunfeng WangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, China. wangchunfeng@jlau.edu.cn.
Guilian YangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, China. yangguilian@jlau.edu.cn.
Jilin Agricultural University · CNJilin University · CN

Funding

China Agriculture Research System of MOF and MARA CARS-35National Natural Science Foundation of China 32072888National Natural Science Foundation of China U21A20261Science and Technology Development Program of Jilin Province 20220202057NCScience and Technology Development Program of Jilin Province 20230202080NCScience and Technology Development Program of Jilin Province YDZJ202301ZYTS326
6 · The paper itself

Abstract

Periodontitis is an inflammatory condition of the oral cavity caused by a mixed infection of various bacteria, which not only severely affects the alveolar bone and connective tissues but also displays potential correlations with distal intestinal inflammation. In this study, we aimed to elucidate the therapeutic effects of Streptococcus cristatus CA119 on experimental periodontitis in rats and its impact on intestinal morphology. The results demonstrate that CA119 is capable of colonizing the oral cavity and exerting antagonistic effects on Porphyromonas gingivalis and Fusobacterium nucleatum, thus leading to a significant reduction in the oral pathogen load. Following CA119 intervention, there was a significant alleviation of weight loss in rats induced by periodontitis (P < 0.001). CA119 also regulated the expression of IL-6 (P < 0.05), IL-1β (P < 0.001), IL-18 (P < 0.001), COX-2 (P < 0.001), iNOS (P < 0.001), and MCP-1 (P < 0.01) in the gingival tissue. Additionally, CA119 reduced oxidative stress levels in rats and enhanced their antioxidant capacity. Microcomputed tomography (micro-CT) and histological analysis revealed that CA119 significantly reduced alveolar bone loss and reversed the downregulation of OPG/RANKL (P < 0.001). Furthermore, CA119 exhibited a significant protective effect against intestinal inflammation induced by periodontal disease and improved the colonic morphology in rats. In conclusion, this study demonstrates the role of CA119 as a potential oral probiotic in the prevention and treatment of experimental periodontitis, underscoring the potential of probiotics as a complementary approach to traditional periodontal care.

Indexed as

PeriodontitisProbioticsStreptococcusAnimalsDisease Models, AnimalFusobacterium nucleatumMaleOxidative StressPorphyromonas gingivalisRatsRats, Sprague-DawleyAntibacterial activityBone lossExperimental periodontitisOxidative stressStreptococcus cristatus CA119

Identifiers

PMID38607584
OpenAlexW4394751565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.