Evidence map›Paper›PMID 38607417›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024

Higher prevalence of thyroid-specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007-2010.

Jialu Wu, Jian Li, Zhe Yan, Xijie Yu, Hui Huang

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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  4. Comment on "Higher prevalence of thyroid‑specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007-2010".Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jialu WuLaboratory of Endocrinology and Metabolism/ Department of Endocrinology and Metabolism, Rare Disease Center, West China Hospital, Sichuan University, No. 37, Guoxue Xiang, Chengdu, 610041, China.
Jian LiLaboratory of Endocrinology and Metabolism/ Department of Endocrinology and Metabolism, Rare Disease Center, West China Hospital, Sichuan University, No. 37, Guoxue Xiang, Chengdu, 610041, China.
Zhe YanDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, No. 37, Guoxue Xiang, Chengdu, 610041, China.
Xijie YuLaboratory of Endocrinology and Metabolism/ Department of Endocrinology and Metabolism, Rare Disease Center, West China Hospital, Sichuan University, No. 37, Guoxue Xiang, Chengdu, 610041, China. xijieyu@scu.edu.cn.ORCID http://orcid.org/0000-0002-3504-7664
Hui HuangDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, No. 37, Guoxue Xiang, Chengdu, 610041, China. sansan1880@126.com.ORCID http://orcid.org/0000-0002-2279-8418
Sichuan University · CN

Funding

Chengdu Science and Technology Program 2022-YF05-01316-SNNational Natural Science Foundation of China 82273294Sichuan Province Science and Technology Support Program 2022YFS0136West China Hospital, Sichuan University 2018SCUH0093West China Hospital, Sichuan University 2020HXFH008West China Hospital, Sichuan University No. ZYJC18003
6 · The paper itself

Abstract

A retrospective analysis was conducted using data from the NHANES. Bone mineral density (BMD) was compared in different thyroid-specific autoantibodies groups. Strengths of associations were calculated by using binary logistic regression models. Higher titers of thyroid-specific autoantibodies (TgAb and/or TPOAb) may lead to decreased BMD. Higher prevalence of TgAb and TPOAb significantly associated with fractures in females but not in males. PURPOSE: Hashimoto's thyroiditis is characterized by elevated thyroid-specific autoantibodies. It is currently believed that osteoporosis is not only a disease with abnormal mineral metabolism but also with immune abnormalities. This study investigated the relationship between thyroid-specific autoantibodies and osteoporosis, including the bone mineral density (BMD) values and fractures.

methodsA retrospective analysis was conducted using data from the National Health and Nutrition Examination Survey (2007-2010). BMD was compared in different thyroid-specific autoantibodies groups. The associations between thyroid-specific autoantibodies and fractures were explored. Strengths of associations were calculated by binary logistic regression models. Candidate variables for binary logistic regression model were selected after screened in univariate analysis (variables with P < 0.05).

resultsA total of 3865 study participants were included in this analysis; 224 participants were TgAb positive and 356 were TPOAb positive. A total of 392 participants reported hip, spine or wrist fractures. Participants with higher prevalence of TgAb or TPOAb had lower BMD. In females, significant cigarettes use, higher prevalence of TgAb and TPOAb, and the BMD of the total femur and femoral neck were significantly associated with fractures. Higher prevalence of TPOAb was particularly associated with a higher possibility of hip or spine fractures. In males, significant cigarettes use, 25OHD3, the BMD values of the total femur, femoral neck and total spine were significantly associated with fractures.

conclusionHigher prevalence of thyroid-specific autoantibodies may lead to decreased BMD. In females, higher prevalence of TgAb and TPOAb significantly associated with fractures and TPOAb especially relating to the fractures of hip and spine. Males patients with vitamin D deficiency or insufficiency associated a higher possibility of fractures.

Indexed as

AutoantibodiesBone DensityNutrition SurveysOsteoporotic FracturesAdultAgedFemaleHumansIodide PeroxidaseMaleMiddle AgedOsteoporosisPrevalenceRetrospective StudiesSex FactorsUnited Statesanti-thyroglobulinAutoantibodiesIodide PeroxidaseBone mineral densityFracturesHashimoto’s thyroiditisThyroglobulin antibodiesThyroid peroxidase antibodies

Identifiers

PMID38607417
OpenAlexW4394751933

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.