Evidence map›Paper›PMID 38607416›Full record

ArticleBioprocess and biosystems engineering2024

Enhanced bactericidal, antibiofilm and antioxidative response of Lawsonia inermis leaf extract synthesized ZnO NPs loaded with commercial antibiotic.

Balasubramanian Malaikozhundan, Sonaimuthu Mohandoss, Raman Krishnamoorthi, Palanichamy Vidhya Bharathi, Subramanian Palanisamy, Jayaraj Vinodhini

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Article in Bioprocess and biosystems engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Balasubramanian Malaikozhundan *Department of Biology, The Gandhigram Rural Institute (Deemed to Be University), 624 302, Gandhigram, Dindigul District, Tamil Nadu, India. kozhundan.malai@gmail.com.
Sonaimuthu Mohandoss *School of Chemical Engineering, Yeungnam University, 38541, Gyeongsan, Republic of Korea.
Raman KrishnamoorthiDepartment of Biology, The Gandhigram Rural Institute (Deemed to Be University), 624 302, Gandhigram, Dindigul District, Tamil Nadu, India.
Palanichamy Vidhya BharathiDepartment of Biology, The Gandhigram Rural Institute (Deemed to Be University), 624 302, Gandhigram, Dindigul District, Tamil Nadu, India.
Subramanian PalanisamyEast Coast Life Sciences Institute, Gangneung-Wonju National University, 120, Gangneung, 210-702, Gangwon, Republic of Korea.
Jayaraj VinodhiniDepartment of Biotechnology, Dr. Umayal Ramanathan College for Women, Alagappa University, 630 003, Karaikudi, Tamil Nadu, India.
Gandhigram Rural Institute · INChang Gung University · TWGangneung–Wonju National University · KRSocial Service Sericulture Project Trust · INYeungnam University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, antibiotic resistance is a challenging issue in healthcare sector. The emergence of multiple drug-resistant bacteria has forced us to modify existing medicines and or formulate newer medicines that are effective and inexpensive. In this perspective, this study involves the formation of zinc oxide nanoparticles (ZnO NPs) by utilizing the Lawsonia inermis (Li) leaf extract. The prepared L. inermis leaf extract mediated ZnO NPs (Li-ZnO NPs) were bio-physically characterized. The antibacterial and radical scavenging effects of Li-ZnO NPs were evaluated. In addition, ZnO NPs were conjugated with standard antibiotic (ciprofloxacin) and its drug loading efficiency, drug release and antibacterial efficacy were tested and compared with non-drug loaded ZnO NPs. An absorbance peak at 340 nm was noted for Li-ZnO NPs. After conjugation with the drug, two absorbance peaks- one at 242 nm characteristic of ciprofloxacin and the other at 350 nm characteristics of ZnO NPs were observed. The crystallite size was 18.7 nm as determined by XRD. The antibacterial effect was higher on Gram-positive (S. aureus and S. pyogenes) than the Gram-negative pathogens (E. coli and K. pneumoniae). Inhibition of S. aureus and S. pyogenes biofilm at 100 μg mL

Indexed as

Anti-Bacterial AgentsAntioxidantsBiofilmsLawsonia PlantPlant ExtractsPlant LeavesZinc OxideCiprofloxacinMetal NanoparticlesMicrobial Sensitivity TestsAnti-Bacterial AgentsAntioxidantsCiprofloxacinPlant ExtractsZinc OxideAntibioticDrug releaseDwarf shrubMDRNanomedicine

Identifiers

PMID38607416
OpenAlexW4394765407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.