Evidence map›Paper›PMID 38607378›Full record

ArticleHeart and vessels2024

Outcomes of patients with cerebral microbleeds undergoing percutaneous coronary intervention and dual antiplatelet therapy.

Masashi Fujino, Teruo Noguchi, Takako Torii-Yoshimura, Yoshinori Okuno, Yoshiaki Morita, Kunihiro Nishimura, Fumiyuki Otsuka, Yu Kataoka, Yasuhide Asaumi, Hiroshi Yamagami and 1 more

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Article in Heart and vessels, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Masashi FujinoDepartment of Cardiovascular Medicine, Suita, Osaka, Japan. fujinom@ncvc.go.jp.ORCID http://orcid.org/0000-0002-2706-4317
Teruo NoguchiDepartment of Cardiovascular Medicine, Suita, Osaka, Japan.
Takako Torii-YoshimuraStroke and Cerebrovascular Disease, Suita, Osaka, Japan.
Yoshinori OkunoDepartment of Primary Care and Emergency Medicine/Healthcare Epidemiology, Kyoto university, Kyoto, Japan.
Yoshiaki MoritaRadiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Kunihiro NishimuraPreventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Fumiyuki OtsukaDepartment of Cardiovascular Medicine, Suita, Osaka, Japan.
Yu KataokaDepartment of Cardiovascular Medicine, Suita, Osaka, Japan.
Yasuhide AsaumiDepartment of Cardiovascular Medicine, Suita, Osaka, Japan.
Hiroshi YamagamiDepartment of Stroke Neurology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Satoshi YasudaDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
National Cerebral and Cardiovascular Center · JPOsaka National Hospital · JPTohoku University · JP

Funding

The Intramural Research Fund for Cardiovascular disease of the National Cerebral and Cardiovascular Center 23-B-7
6 · The paper itself

Abstract

introductionCerebral microbleeds (CMBs) on brain magnetic resonance imaging (MRI) are predictive of intracerebral hemorrhage (ICH). However, the risk of ICH in patients with CMBs who undergo percutaneous coronary intervention (PCI) while receiving dual antiplatelet therapy (DAPT) is unclear. MATERIALS AND

methodsWe conducted a study on 329 consecutive patients with coronary artery disease who underwent PCI and were evaluated using a 3T MRI scanner. Based on T2*-weighted imaging, patients were classified into three groups: no CMBs, < 5 CMBs, or ≥ 5 CMBs. We determined the occurrence of ICH during follow-up.

resultsAt least 1 CMB was found in 109 (33%) patients. The mean number of CMBs per patient was 2.9 ± 3.6. Among the 109 patients with CMBs, 16 (15%) had ≥ 5 CMBs. Coronary stent implantation was performed in 321 patients (98%). DAPT was prescribed for 325 patients (99%). During a mean follow-up period of 2.3 years (interquartile range, 1.9-2.5 years), ICH occurred in one patient (1.1%) with four CMBs. There were no significant differences in the incidence of ICH (0% vs. 1.1% vs. 0%; p = 0.28). However, the rate of DAPT at 6 months of follow-up was significantly lower in patients with ≥ 5 CMBs than in patients with no CMBs or < 5 CMBs (89% vs. 91% vs. 66%, p = 0.026). Furthermore, there were no significant differences in systemic blood pressure during follow-up (123 ± 16 vs. 125 ± 16 vs. 118 ± 11 mmHg; p = 0.40).

conclusionAlthough a substantial number of patients who underwent PCI had cerebral microbleeds, at approximately two years of follow-up, intracerebral hemorrhage was very rare in our study population.

Indexed as

Cerebral HemorrhageCoronary Artery DiseaseDual Anti-Platelet TherapyPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsAgedFemaleFollow-Up StudiesHumansIncidenceJapanMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesRisk FactorsPlatelet Aggregation InhibitorsCerebral microbleedsCoronary artery diseaseDual antiplatelet therapyIntracerebral hemorrhage

Identifiers

PMID38607378
OpenAlexW4394754910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.