Evidence map›Paper›PMID 38607065›Full record

ArticleCells2024

SMAD4-Dependent Signaling Pathway Involves in the Pathogenesis of TGFBR2-Related CE-like Phenotype.

Yen-Chiao Wang, Olivia Betty Zolnik, Chia-Yang Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yen-Chiao WangEdith Crawley Vision Research Center, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Olivia Betty ZolnikSchool of Optometry, Indiana University, Bloomington, IN 47405, USA.
Chia-Yang LiuEdith Crawley Vision Research Center, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Indiana University Bloomington · USUniversity of Cincinnati · US

Funding

Molecular mechanism of corneal epithelial stratification and innervationR01EY029071 · NEI · UNIVERSITY OF CINCINNATI · PI LIU, CHIA-YANG · 2019 to 2022
$2.1M
Role of Tgf-beta-signaling in corneal development and diseasesR21EY031051 · NEI · UNIVERSITY OF CINCINNATI · PI LIU, CHIA-YANG · 2020 to 2021
$416k
NEI NIH HHS R01 EY029071NEI NIH HHS R21 EY031051
6 · The paper itself

Abstract

(1) Background: Our previous data indicated that disturbance of the Transforming Growth Factor beta (TGFB) signaling pathway via its Type-2 Receptor (TGFBR2) can cause a Corneal Ectasia (CE)-like phenotype. The purpose of this study is to elucidate whether the SMAD4-dependent signaling pathway is involved in the TGFBR2-related CE-like pathogenesis. (2) Methods:

Indexed as

Corneal DiseasesAnimalsCollagenMiceMice, TransgenicPhenotypeReceptor, Transforming Growth Factor-beta Type IISignal TransductionCollagenReceptor, Transforming Growth Factor-beta Type IICorneal EctasiakeratoconusSMAD4TGFB

Identifiers

PMID38607065
PMCPMC11011447
OpenAlexW4393935506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.