Evidence map›Paper›PMID 38607036›Full record

ArticleCells2024

CD99 Expression and Prognostic Impact in Glioblastoma: A Single-Center Cohort Study.

Andrea Rocca, Fabiola Giudici, Carmine Antonio Donofrio, Cristina Bottin, Maurizio Pinamonti, Benvenuto Ferrari, Francesco Schettini, Estela Pineda, Stefano Panni, Marika Cominetti and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 2 countries.

Andrea RoccaDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.ORCID 0000-0003-4613-8884
Fabiola GiudiciCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-4160-3479
Carmine Antonio DonofrioNeurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.ORCID 0000-0002-9123-8158
Cristina BottinDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.
Maurizio PinamontiDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.
Benvenuto FerrariBreast and Brain Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Francesco SchettiniTranslational Genomics and Targeted Therapies in Solid Tumors Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), C. Villaroel 170, 08036 Barcelona, Spain.ORCID 0000-0001-6561-1919
Estela PinedaMedical Oncology Department, Hospital Clínic of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-2128-747X
Stefano PanniBreast and Brain Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Marika CominettiNeurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Patrizia D'AuriaNeurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Simonetta BianchiniNeurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Elena VarottiPathology Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Marco UngariPathology Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.ORCID 0000-0002-6656-8593
Stefano CiccarelliRadiotherapy Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Marzia FilippiniRadiotherapy Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Sarah BrennaRadiotherapy Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Valentina FioriDiatheva srl, 61030 Cartoceto, Italy.ORCID 0009-0002-3756-6983
Tomas Di MambroDiatheva srl, 61030 Cartoceto, Italy.
Angelo SpartiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.ORCID 0009-0003-5496-0250
Mauro MagnaniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.ORCID 0000-0001-6456-6626
Fabrizio ZanconatiDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.
Daniele GeneraliDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.ORCID 0000-0001-6002-1530
Antonio FioravantiNeurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
Azienda Socio Sanitaria Territoriale di CremonaUniversity of Trieste · ITDepartament de Salut · ESIstituti Ospitalieri di Cremona · ITUniversity of Urbino · ITCentro di Riferimento Oncologico · IT

Funding

MEDnoTE Srl (a spin-off of the University of Trieste)
6 · The paper itself

Abstract

Glioblastoma is the most frequent and aggressive brain tumor in adults. This study aims to evaluate the expression and prognostic impact of CD99, a membrane glycoprotein involved in cellular migration and invasion. In a cohort of patients with glioblastoma treated with surgery, radiotherapy and temozolomide, we retrospectively analyzed tumor expression of CD99 by immunohistochemistry (IHC) and by quantitative real-time polymerase chain reaction (qRT-PCR) for both the wild type (CD99wt) and the truncated (CD99sh) isoforms. The impact on overall survival (OS) was assessed with the Kaplan-Meier method and log-rank test and by multivariable Cox regression. Forty-six patients with glioblastoma entered this study. Immunohistochemical expression of CD99 was present in 83%. Only the CD99wt isoform was detected by qRT-PCR and was significantly correlated with CD99 expression evaluated by IHC (rho = 0.309,

Indexed as

Glioblastoma12E7 AntigenAdultCohort StudiesHumansPrognosisRetrospective StudiesTemozolomide12E7 AntigenCD99 protein, humanTemozolomideCD99glioblastomaimmunohistochemistryprognostic factorquantitative real-time polymerase chain reaction

Identifiers

PMID38607036
PMCPMC11012029
OpenAlexW4393317718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.