Evidence map›Paper›PMID 38607000›Full record

ReviewCells2024

Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma.

Lia Rodrigues, Arnaud Da Cruz Paula, Paula Soares, João Vinagre

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  2. Review
  3. Article
  4. Regulation of the microprocessor by post-translational modifications.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lia RodriguesInstituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Rua Alfredo Allen, 4200-135 Porto, Portugal.ORCID 0000-0002-3718-1111
Arnaud Da Cruz PaulaInstituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Rua Alfredo Allen, 4200-135 Porto, Portugal.
Paula SoaresInstituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Rua Alfredo Allen, 4200-135 Porto, Portugal.ORCID 0000-0001-9607-6998
João VinagreInstituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Rua Alfredo Allen, 4200-135 Porto, Portugal.ORCID 0000-0002-0871-1427
Universidade do Porto · PT

Funding

European Union 2022-C05IO101-02-Agenda Illiance (Bosch, project nº 46)-PPS4-OLI health", with reference C644919832-00000035, funded by PRR-Plano de Recuperação e Resiliên-cia e pelos Fundos Europeus NextGenerationEU, através do sistema de incentivos «Agendas para a InovEuropean Union NORTE-01-0145-FEDER-000051Fundação para a Ciência e Tecnologia 2022.00276.CEECINDFundação para a Ciência e Tecnologia 2023.03099.BDFundação para a Ciência e Tecnologia PTDC/MED-ONC/0531/2021
6 · The paper itself

Abstract

MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting

Indexed as

MicroRNAsThyroid NeoplasmsCell DifferentiationHumansMutationRNA-Binding ProteinsDGCR8 protein, humanMicroRNAsRNA-Binding ProteinsDGCR8E518KmicroRNAsthyroid cancer

Identifiers

PMID38607000
PMCPMC11011343
OpenAlexW4393094282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.