Evidence map›Paper›PMID 38606906›Full record

ArticleExperimental physiology2024

Maternal tadalafil treatment does not increase uterine artery blood flow or oxygen delivery in the pregnant ewe.

Jack R T Darby, Dimitra Flouri, Steven K S Cho, Georgia K Williams, Stacey L Holman, Ashley S Meakin, Michael D Wiese, Anna L David, Christopher K Macgowan, Mike Seed and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Jack R T DarbyEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0001-7114-3920
Dimitra FlouriSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID 0000-0002-8846-3573
Steven K S ChoEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Georgia K WilliamsPreclinical, Imaging & Research Laboratories, South Australian Health & Medical Research Institute, Adelaide, Australia.ORCID 0000-0002-5529-1322
Stacey L HolmanEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0002-6326-4797
Ashley S MeakinEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0003-2806-6274
Michael D WieseCentre for Pharmaceutical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0002-3255-9242
Anna L DavidElizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.ORCID 0000-0002-0199-6140
Christopher K MacgowanUniveristy of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-7016-0662
Mike SeedUniveristy of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-7330-234X
Andrew MelbourneSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID 0000-0001-7667-3947
Janna L MorrisonEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0002-8602-8519
University of South Australia · AUHospital for Sick Children · CAKing's College London · GBSouth Australian Health and Medical Research Institute · AUUniversity College Hospital · GB

Funding

Ames Research Center NASA DP190102263Ames Research Center NASA FT170100431
6 · The paper itself

Abstract

Increasing placental perfusion (PP) could improve outcomes of growth-restricted fetuses. One way of increasing PP may be by using phosphodiesterase (PDE)-5 inhibitors, which induce vasodilatation of vascular beds. We used a combination of clinically relevant magnetic resonance imaging (MRI) techniques to characterize the impact that tadalafil infusion has on maternal, placental and fetal circulations. At 116-117 days' gestational age (dGA; term, 150 days), pregnant ewes (n = 6) underwent fetal catheterization surgery. At 120-123 dGA ewes were anaesthetized and MRI scans were performed during three acquisition windows: a basal state and then ∼15-75 min (TAD 1) and ∼75-135 min (TAD 2) post maternal administration (24 mg; intravenous bolus) of tadalafil. Phase contrast MRI and T

Indexed as

OxygenPlacentaPlacental CirculationTadalafilUterine ArteryAnimalsFemaleFetusMagnetic Resonance ImagingPhosphodiesterase 5 InhibitorsPregnancyRegional Blood FlowSheepOxygenPhosphodiesterase 5 InhibitorsTadalafilfetal developmentfetal growth restrictionfetal MRIhaemodynamicsmagnetic resonance imagingplacental perfusiontadafertadalafil

Identifiers

PMID38606906
PMCPMC11140180
OpenAlexW4394762855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.