Evidence map›Paper›PMID 38606861›Full record

ArticleThe world journal of men's health2024

Ferroptosis Is Crucial for Cisplatin Induced Sertoli Cell Injury

Zhongru Fan, Peng Xin, Lin Zhao, Chuize Kong, Chiyuan Piao, Zhengqi Wu, Zhongkai Qiu, Wei Zhao, Zhe Zhang

Open access · diamondAbstract read
In one paragraph

Article in The world journal of men's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 9 citations in OpenAlex.

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  7. Protection byPharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zhongru Fan *Department of Urology, The First Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0002-4376-2924
Peng Xin *Department of Urology, The First Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0003-2620-1188
Lin ZhaoDepartment of Obstetrics and Gynecology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.ORCID https://orcid.org/0000-0001-7541-9410
Chuize KongDepartment of Urology, The First Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0002-0875-2173
Chiyuan PiaoDepartment of Urology, The First Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0001-5919-8865
Zhengqi WuDepartment of Urology, The First Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0003-2322-6259
Zhongkai QiuDepartment of Urology, The First Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0009-0000-5936-7008
Wei ZhaoDepartment of Urology, The First Hospital of China Medical University, Shenyang, China. zhaowei20020226@163.com.ORCID https://orcid.org/0009-0004-8963-5594
Zhe ZhangDepartment of Urology, The First Hospital of China Medical University, Shenyang, China. zzhang@cmu.edu.cn.ORCID https://orcid.org/0000-0003-2766-5902
First Hospital of China Medical University · CNSuzhou Municipal Hospital · CNXian Central Hospital · CN

Funding

Liaoning Plan Project of Science and Technology 2023JH6/100200010
6 · The paper itself

Abstract

purposeThis study aimed to investigate the effect of the N6-methyladenosine (m6A) dependent ferroptosis on cisplatininduced Sertoli cell injury. MATERIALS AND

methodsA cisplatin exposure mouse model was established by intraperitoneal injection of cisplatin in our study. TM4 cell lines was used for

resultsFerroptosis, but not other types of programmed cell death, is a significant phenomenon in cisplatin-induced testis damage and Sertoli cell loss. Ferroptosis induced by cisplatin in Sertoli cell/TM4 cell is GPX4 independent but is regulated by SLC7A11 and ALOX12. Both SLC7A11 and ALOX12 are regulated

conclusionsCisplatin-induced Sertoli cell injury

Indexed as

Blood-testis barrierCisplatinFerroptosisRNA methylationSertoli cells

Identifiers

PMID38606861
PMCPMC11439804
OpenAlexW4393269739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.