Evidence map›Paper›PMID 38606851›Full record

Trial reportJournal of addiction medicine

Discordance Between Insurance Coverage of Antiviral Medications and Nicotine Replacement Therapy Among Individuals With Human Immunodeficiency Virus Who Smoke.

Steven L Bernstein, Jessica E Yager, Keith Sigel, Elizabeth Porter, Tina Do, Erika Payne, Krysten Bold, David Ledgerwood, E Jennifer Edelman

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Steven L BernsteinFrom the C. Everett Koop Institute, Geisel School of Medicine at Dartmouth, Lebanon, NH (SLB); Department of Medicine, Downstate Health Sciences University, New York, NY (JEY); Department of Internal Medicine, Icahn School of Medicine with Mount Sinai, NYC, NY (KS); Department of Medicine, Yale School of Medicine, New Haven, CT (EP, EJE); Department of Psychiatry, Yale School of Medicine, New Haven, CT (KB); Yale New Haven Hospital, New Haven, CT (TD, EP); and Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI (DL).
Jessica E Yager
Keith Sigel
Elizabeth Porter
Tina Do
Erika Payne
Krysten Bold
David Ledgerwood
E Jennifer Edelman
Yale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
A SMART Approach to Treating Tobacco Use Disorder in Persons Living with HIVR01CA243910 · NCI · YALE UNIVERSITY · PI BERNSTEIN, STEVEN L, EDELMAN, E. JENNIFER · 2019 to 2024
$3.4M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA243910
6 · The paper itself

Abstract

introductionTobacco contributes to the leading causes of morbidity and mortality among persons with human immunodeficiency virus (PWHs). Nonetheless, medications for tobacco use disorder are widely underused, particularly among PWHs. We sought to characterize the extent to which insurance barriers impacted access to medications for tobacco use disorder and, in comparison, to access to antiretroviral therapy (ART).

methodsThis is a secondary analysis of data on individuals enrolled in a randomized clinical trial to address tobacco use involving nicotine replacement therapy and, for some, additionally, varenicline or bupropion. Medication prescriptions are transmitted electronically from the clinic to neighborhood pharmacies. Data sources included participant assessments and intervention visit tracking forms.

resultsOf 93 participants enrolled from September 2020 to July 2021, 20 (22%) were unable to fill or had difficulty filling their nicotine replacement therapy (NRT) prescriptions because of insurance barriers. These fell into 2 broad categories: enrollment in a publicly insured managed care plan in which the pharmacy benefit manager excluded nonprescription NRT and lack of understanding by the pharmacy of the scope of coverage. Of these 20 participants, 5 (25%) were unable to obtain medications at all, and 3 of these participants dropped out of the study. One additional participant paid out-of-pocket to obtain NRT. No participant was denied coverage of ART, bupropion, or varenicline.

conclusionsGaps in insurance coverage may result in PWHs receiving ART without simultaneous medical management of their tobacco use. This may undermine the efficacy of antivirals. Mandated insurance coverage of nonprescription NRT may improve the health of PWHs who smoke.

Indexed as

Antiviral AgentsHIV InfectionsInsurance CoverageTobacco Use Cessation DevicesAdultBupropionFemaleHealth Services AccessibilityHumansMaleMiddle AgedNicotine Replacement TherapySmoking Cessation AgentsTobacco Use DisorderVareniclineAntiviral AgentsBupropionSmoking Cessation AgentsVarenicline

Identifiers

PMID38606851
PMCPMC11290992
OpenAlexW4394750899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.