ArticleEuropean heart journal2024
Ischaemic stroke in women with atrial fibrillation: temporal trends and clinical implications.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Gout and Risk of Ischemic Stroke in Patients With Atrial Fibrillation: A Nationwide Cohort Study.Stroke · 2026Observational
- Female sex-related stroke risk in patients with atrial flutter-comparison between CHA2DS2-VA and CHA2DS2-VASc scores.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Predicting common cardiovascular and non-cardiovascular outcomes after new-onset atrial fibrillation: an analysis from a UK nationwide primary-secondary care linkage dataset.European heart journal open · 2026Article
- Trends in Polypharmacy Among Patients With Atrial Fibrillation: A Report From the Finnish AntiCoagulation in Atrial Fibrillation Nationwide Cohort Study.Journal of the American Heart Association · 2026Article
- Breakthrough Stroke in Women With Atrial Fibrillation: A Call for Sex-Specific Care and Better Outcomes.Journal of the American Heart Association · 2026Article
- Sex Differences in Outcomes After Breakthrough Ischemic Stroke on Oral Anticoagulants for Atrial Fibrillation: An ASPERA-R Inverse Probability Weighted Analysis.Journal of the American Heart Association · 2026Article
- Female Sex-Related Stroke Risk in Atrial Fibrillation: A Thing From the Past?Circulation. Arrhythmia and electrophysiology · 2026Article
- Article
- Alcohol use disorder and use of rhythm control therapies in patients with atrial fibrillation: A nationwide cohort study.International journal of cardiology. Heart & vasculature · 2026Article
- Factors associated with oral anticoagulant non-use at first ischemic stroke in atrial fibrillation: A nationwide study.European stroke journal · 2026Article
- Methods Article for a Study Protocol: Refining Stroke Prediction in Atrial Fibrillation Patients in an Ethnically Diverse Population - A Study Protocol.Neuroepidemiology · 2026Article
- Application of Artificial Intelligence in the Early Detection and Management of Atrial Fibrillation: State-of-the-art Review.European cardiology · 2026Review
- Global burden of atrial fibrillation/atrial flutter and its attributable risk factors in adolescents and young adults, 1990-2021: insights from the global burden of disease study.Annals of medicine · 2025Article
- Atrial fibrillation and ischemic stroke in cancer: the latest scientific evidence, current management, and future directions.Journal of thrombosis and thrombolysis · 2025Review
- Sex differences in the initiation of antithrombotic therapy in patients with atrial fibrillation in Germany.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- How much does elective cardioversion increase the risk of ischaemic stroke compared to the baseline risk in atrial fibrillation? A nationwide study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Stroke risk stratifications according to CHA2DS2-VASc vs. CHA2DS2-VA in patients with atrial fibrillation: insights from the GLORIA-AF registry.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- The 2024 ESC guidelines on atrial fibrillation: essential updates for everyday clinical practice.Internal and emergency medicine · 2025Article
- Incidence, risk factors, and mortality of pulmonary embolism in the Netherlands (2015-22): sex differences and shifts during the coronavirus disease 2019 pandemic.European heart journal · 2025Article
- Temporal Trends in the Association Between Female Sex and Ischemic Stroke Among Patients With Atrial Fibrillation.Journal of the American Heart Association · 2025Article
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
aimsFemale sex has been linked with higher risk of ischaemic stroke (IS) in atrial fibrillation (AF), but no prior study has examined temporal trends in the IS risk associated with female sex.
methodsThe registry-linkage Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) study included all patients with AF in Finland from 2007 to 2018. Ischaemic stroke rates and rate ratios were computed.
resultsOverall, 229 565 patients with new-onset AF were identified (50.0% women; mean age 72.7 years). The crude IS incidence was higher in women than in men across the entire study period (21.1 vs. 14.9 events per 1000 patient-years, P < .001), and the incidence decreased both in men and women. In 2007-08, female sex was independently associated with a 20%-30% higher IS rate in the adjusted analyses, but this association attenuated and became statistically non-significant by the end of the observation period. Similar trends were observed when time with and without oral anticoagulant (OAC) treatment was analysed, as well as when only time without OAC use was considered. The decrease in IS rate was driven by patients with high IS risk, whereas in patients with low or moderate IS risk, female sex was not associated with a higher IS rate.
conclusionsThe association between female sex and IS rate has decreased and become non-significant over the course of the study period from 2007 to 2018, suggesting that female sex could be omitted as a factor when estimating expected IS rates and the need for OAC therapy in patients with AF.
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