ArticleJournal of the American Heart Association2024
A Comparison of 5 Measures of Accelerated Biological Aging and Their Association With Incident Cardiovascular Disease: The CARDIA Study.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Assessing differences in epigenetic aging markers between sexual or gender minority and straight cisgender adults using the Coronary Artery Risk Development in Young Adults cohort.Social science & medicine (1982) · 2026Article
- Article
- The distinctiveness of human aging I: Anthropological and developmental foundations.Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- Estimating Vascular Age to Evaluate the Association Between Aging and Cardiovascular Disease.Aging cell · 2026Article
- Associations of Biological Age and Heart Age Accelerations With New-Onset Stroke in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From a Chinese Longitudinal Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study.Aging cell · 2026Article
- Contributions of Biological Aging to Longitudinal Incidence and Dynamic Progression of Atrial Fibrillation: A Prospective Cohort Study.Reviews in cardiovascular medicine · 2026Article
- Association of biological age acceleration with cardiovascular disease and premature mortality: a population-based prospective cohort study.Frontiers in public health · 2026Article
- Age- and Sex-Adjusted Myocardial Flow Reserve Percentiles for Personalized Cardiovascular Risk Assessment.medRxiv : the preprint server for health sciences · 2025Article
- The B-SCancers · 2025Article
- Changes in accelerated aging and risk of cardiovascular disease and mortality: three cohort studies.BMC medicine · 2025Article
- What's counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations.Clinical epigenetics · 2025Review
- Epigenetic clocks of biological aging and risk of incident mild cognitive impairment and dementia: the Women's Health Initiative Memory Study.medRxiv : the preprint server for health sciences · 2025Article
- Association of biological aging acceleration transitions and burdens with incident cardiovascular disease: longitudinal insights from a national cohort study.BMC medicine · 2025Article
- Methylation-based biological age and cardiotoxicity risk in breast cancer patients treated with trastuzumab.Cardio-oncology (London, England) · 2025Article
- Dietary Carbohydrate Quality Is Associated with Epigenetic Age Acceleration: a Cross-Sectional Study of the CARDIA Cohort.The Journal of nutrition · 2025Article
- Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk.Investigative ophthalmology & visual science · 2025Article
- Young users of electronic cigarettes exhibit reduced cardiorespiratory fitness.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccelerated biological aging is an increasingly popular way to track the acceleration of biology over time that may not be captured by calendar time. Biological aging has been linked to external and internal chronic stressors and has the potential to be used clinically to understand a person's personalized functioning and predict future disease. We compared the association of different measures of biological aging and incident cardiovascular disease (CVD) overall and by race. METHODS AND
resultsWe used multiple informants models to compare the strength of clinical marker-derived age acceleration, 5 measures of epigenetic age acceleration (intrinsic and extrinsic epigenetic age acceleration, GrimAge acceleration, and PhenoAge acceleration), and 1 established clinical predictor of future CVD, Framingham 10-year risk score, with incident CVD over an 11-year period (2007-2018). Participants were 913 self-identified Black or White (41% and 59%, respectively) female or male (51% and 49%, respectively) individuals enrolled in the US-based CARDIA (Coronary Artery Risk Development in Young Adults) cohort study. The analytic baseline for this study was the 20-year follow-up examination (2005-2006; median age 45 years). We also included race-specific analysis. We found that all measures were modestly correlated with one another. However, clinical marker-derived age acceleration and Framingham 10-year risk score were more strongly associated with incident CVD than all the epigenetic measures. Clinical marker-derived age acceleration and Framingham 10-year risk score were not significantly different than one another in their association with incident CVD.
conclusionsThe type of accelerated aging measure should be taken into consideration when comparing their association with clinical outcomes. A multisystem clinical composite shows associations with incident CVD equally to a well-known clinical predictor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.