Evidence map›Paper›PMID 38606596›Full record

ArticleThe British journal of nutrition2024

Enhancing selection of alcohol consumption-associated genes by random forest.

Chenglin Lyu, Roby Joehanes, Tianxiao Huan, Daniel Levy, Yi Li, Mengyao Wang, Xue Liu, Chunyu Liu, Jiantao Ma

Open access · bronzeAbstract read
In one paragraph

Article in The British journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chenglin LyuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA02118, USA.ORCID 0009-0005-8723-8752
Roby JoehanesFramingham Heart Study and Population Sciences Branch, NHLBI, Framingham, MA01702, USA.
Tianxiao HuanFramingham Heart Study and Population Sciences Branch, NHLBI, Framingham, MA01702, USA.
Daniel LevyFramingham Heart Study and Population Sciences Branch, NHLBI, Framingham, MA01702, USA.
Yi LiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA02118, USA.
Mengyao WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA02118, USA.
Xue LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA02118, USA.
Chunyu Liu *Department of Biostatistics, Boston University School of Public Health, Boston, MA02118, USA.
Jiantao Ma *Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA02111, USA.
Boston University · USFramingham Heart Study · USTufts University · US

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Trans-omic Analysis of Alcohol Consumption and its Relation to Cardiovascular DiseaseR01AA028263 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LIU, CHUNYU, MA, JIANTAO · 2021 to 2025
$2.6M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NIAAA NIH HHS R01 AA028263
6 · The paper itself

Abstract

Machine learning methods have been used in identifying omics markers for a variety of phenotypes. We aimed to examine whether a supervised machine learning algorithm can improve identification of alcohol-associated transcriptomic markers. In this study, we analysed array-based, whole-blood derived expression data for 17 873 gene transcripts in 5508 Framingham Heart Study participants. By using the Boruta algorithm, a supervised random forest (RF)-based feature selection method, we selected twenty-five alcohol-associated transcripts. In a testing set (30 % of entire study participants), AUC (area under the receiver operating characteristics curve) of these twenty-five transcripts were 0·73, 0·69 and 0·66 for non-drinkers

Indexed as

Alcohol DrinkingAlgorithmsAdultCardiovascular DiseasesFemaleHumansMachine LearningMaleMiddle AgedRandom ForestRisk FactorsSupervised Machine LearningTranscriptomeAlcohol consumptionBorutaCVDGene expressionMachine learningrandom forest

Identifiers

PMID38606596
PMCPMC11216877
OpenAlexW4394762813

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.