Evidence map›Paper›PMID 38606464›Full record

ArticleACS infectious diseases2024

Target-Mediated Fluoroquinolone Resistance in

Jessica A Collins, Alexandria A Oviatt, Pan F Chan, Neil Osheroff

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Antibacterial photoswitchable triazenic ciprofloxacins.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. AssessingbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Antibacterial and Synergistic Effects ofAntibiotics (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Fluoroquinolones and Biofilm: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  17. Article
  18. Article
  19. bioRxiv : the preprint server for biology · 2024
    Article
  20. Interactions between Zoliflodacin andACS infectious diseases · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jessica A CollinsDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-4077-1016
Alexandria A OviattDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-4629-7642
Pan F ChanInfectious Diseases Research Unit, GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States.
Neil OsheroffDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-2550-4884
Vanderbilt University · USGlaxoSmithKline (United States) · US

Funding

Mechanistic Studies of Gyrase/Topoisomerase IV-Targeted AntibacterialsR01AI170546 · NIAID · VANDERBILT UNIVERSITY · PI NEIL OSHEROFF · 2023 to 2026
$2.7M
Mechanistic Studies of Type II Topoisomerases and Topoisomerase-Targeted AgentsR01GM126363 · NIGMS · VANDERBILT UNIVERSITY · PI OSHEROFF, NEIL · 2018 to 2025
$2.6M
Actions of spiropyrimidinetriones against bacterial type II topoisomerasesF31AI174684 · NIAID · VANDERBILT UNIVERSITY · PI COLLINS, JESSICA A · 2023 to 2023
$31k
Mechanism of Quinolone ResistanceI01BX002198 · VA · VETERANS HEALTH ADMINISTRATION · PI OSHEROFF, NEIL · 2015 to 2023
–
BLRD VA I01 BX002198NIAID NIH HHS F31 AI174684NIAID NIH HHS R01 AI170546NIGMS NIH HHS R01 GM126363
6 · The paper itself

Abstract

Fluoroquinolones make up a critically important class of antibacterials administered worldwide to treat human infections. However, their clinical utility has been curtailed by target-mediated resistance, which is caused by mutations in the fluoroquinolone targets, gyrase and topoisomerase IV. An important pathogen that has been affected by this resistance is

Indexed as

CiprofloxacinGonorrheaDNA GyraseDNA Topoisomerase IVFluoroquinolonesHumansMicrobial Sensitivity TestsNeisseria gonorrhoeaeCiprofloxacinDNA GyraseDNA Topoisomerase IVFluoroquinolonesciprofloxacinDNA cleavageDNA supercoiling/decatenationfluoroquinolonegyrasetopoisomerase IV

Identifiers

PMID38606464
PMCPMC11015056
OpenAlexW4392377259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.