Evidence map›Paper›PMID 38606369›Full record

SynthesisFrontiers in pediatrics2024

Pediatric COVID-19 in Argentina: a comprehensive analysis of disease and economic burden through official data and a systematic literature review.

Ariel Bardach, Silvina Ruvinsky, Carolina Moreno, Lucas Perelli, Moe H Kyaw, Julia Spinardi, Carlos Fernando Mendoza, Carolina M Carballo, Macarena Roel, Natalia Espinola

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ariel BardachDepartment of Health Technology Assessment and Health Economics, Institute for Clinical Effectiveness and Health Policy (IECS), Ciudad Autónoma de Buenos Aires, Argentina.
Silvina RuvinskyDepartment of Health Technology Assessment and Health Economics, Institute for Clinical Effectiveness and Health Policy (IECS), Ciudad Autónoma de Buenos Aires, Argentina.
Carolina MorenoDepartment of Health Technology Assessment and Health Economics, Institute for Clinical Effectiveness and Health Policy (IECS), Ciudad Autónoma de Buenos Aires, Argentina.
Lucas PerelliDepartment of Health Technology Assessment and Health Economics, Institute for Clinical Effectiveness and Health Policy (IECS), Ciudad Autónoma de Buenos Aires, Argentina.
Moe H KyawVaccine Scientific Affairs, Pfizer Inc., New York, NY, United States.
Julia SpinardiVaccine Medical Affairs, Emerging Markets, Pfizer Inc., Itapevi, Brazil.
Carlos Fernando MendozaVaccine HTA, Value and Evidence, Pfizer Inc., Mexico City, Mexico.
Carolina M CarballoVaccine Medical Manager, Pfizer Inc., Buenos Aires City, Argentina.
Macarena RoelResearch Department, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
Natalia EspinolaDepartment of Health Technology Assessment and Health Economics, Institute for Clinical Effectiveness and Health Policy (IECS), Ciudad Autónoma de Buenos Aires, Argentina.
Instituto de Efectividad Clínica y Sanitaria · ARPfizer (United States) · USGarrahan Hospital · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Limited data are available on the clinical impact and economic burden of COVID-19 in the pediatric population in Argentina. We aimed to estimate the disease and economic burden of COVID-19 on children and adolescents. Methods: We analyzed official national databases and conducted a supplemental systematic review of the published literature with meta-analysis in children aged 0-18. The period of interest was from March 2020 to August 2021, before the introduction of vaccination in this age group as a national strategic plan. In addition, we used a cost of illness analysis to estimate the direct medical costs associated with COVID-19. All costs are reported in US dollars 2023. Results: A total of 450,503 confirmed COVID-19 cases and 180 multisystem inflammatory syndrome (MIS-C) were reported in Argentina in the study period. Fourteen observational clinical studies were identified. The meta-analyses of severity level from hospital patients showed that according to different studies 15%-28% of cases were asymptomatic, 68%-88% were mild or moderate, and 3%-10% were severe or critical. About 28% of children had an underlying disease. In addition, the estimated economic burden associated with COVID-19 was 80 million dollars and 4 million dollars corresponded to MISC. Conclusion: Significant impact of COVID-19 on the healthcare system and substantial economic implications for the pediatric population in Argentina were identified. The findings should help policymakers to make informed decisions and allocate resources effectively.

Indexed as

Argentinadisease burdeneconomic burdenmeta-analysismultisystem inflammatory syndromepediatric COVID-19systematic review

Identifiers

PMID38606369
PMCPMC11007211
OpenAlexW4393276737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.