Evidence map›Paper›PMID 38606284›Full record

ArticleTetrahedron chem2022

Synthesis of (-)-melazolide B, a degraded limonoid, from a natural terpene precursor.

Yannan Liu, Alexander W Schuppe, Yizhou Zhao, Jaehoo Lee, Timothy R Newhouse

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron chem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yannan LiuDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, CT, 06520-8107, United States.
Alexander W SchuppeDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, CT, 06520-8107, United States.
Yizhou ZhaoDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, CT, 06520-8107, United States.
Jaehoo LeeDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, CT, 06520-8107, United States.
Timothy R NewhouseDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, CT, 06520-8107, United States.

Funding

Synthesis of Neurologically Active Small MoleculesR01GM118614 · NIGMS · YALE UNIVERSITY · PI NEWHOUSE, TIMOTHY · 2017 to 2025
$3.1M
NIGMS NIH HHS R01 GM118614
6 · The paper itself

Abstract

Degraded limonoids are a subclass of limonoid natural products that derive from ring-intact or ring-rearranged limonoids. Establishment of robust synthetic routes to access them could provide valuable materials to identify the simplest active pharmacophore responsible for the observed biological activities of the parent molecules. This communication delineates the development of a divergent strategy to furnish melazolide B and several other related congeners from a common keto-lactone intermediate, which was rapidly assembled from α-ionone. A chemoselective carbonyl α,β-dehydrogenation and a Wharton reduction were key strategic steps in this synthetic pathway.

Indexed as

LimonoidMelazolide BNatural productTerpenoidTotal synthesis

Identifiers

PMID38606284
PMCPMC11008529

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.