Evidence map›Paper›PMID 38605941›Full record

ArticleFrontiers in immunology2024

Is the exquisite specificity of lymphocytes generated by thymic selection or due to evolution?

Rob J De Boer, Can Kesmir, Alan S Perelson, José A M Borghans

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rob J De BoerTheoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands.
Can KesmirTheoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands.
Alan S PerelsonDepartment of Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, United States.
José A M BorghansCenter for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

Funding

Immune System Modeling/HIVR01AI028433 · NIAID · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 1990 to 2021
$3.7M
NIAID NIH HHS R01 AI028433
6 · The paper itself

Abstract

We have previously argued that the antigen receptors of T and B lymphocytes evolved to be sufficiently specific to avoid massive deletion of clonotypes by negative selection. Their optimal 'specificity' level, i.e., probability of binding any particular epitope, was shown to be inversely related to the number of self-antigens that the cells have to be tolerant to. Experiments have demonstrated that T lymphocytes also

Indexed as

Thymus GlandT-Lymphocytes, RegulatoryAutoantigensB-LymphocytesEpitopesAutoantigensEpitopesevolutionnegative selectionrepertoire diversityT cell repertoireT cell specificity

Identifiers

PMID38605941
PMCPMC11008227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.