Evidence map›Paper›PMID 38605658›Full record

Trial reportJournal of psychopharmacology (Oxford, England)2024

Psychedelics and the 'inner healer': Myth or mechanism?

Joseph Peill, Miriam Marguilho, David Erritzoe, Tommaso Barba, Kyle T Greenway, Fernando Rosas, Christopher Timmermann, Robin Carhart-Harris

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of psychopharmacology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. The entropic brain today.Brain : a journal of neurology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph PeillDivision of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.ORCID 0000-0003-0281-4617
Miriam MarguilhoDivision of Psychiatry, Lisbon Psychiatric Hospital Centre, Lisbon, Portugal.
David ErritzoeDivision of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.ORCID 0000-0002-7022-6211
Tommaso BarbaDivision of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.ORCID 0000-0003-2565-4628
Kyle T GreenwayDivision of Psychiatry, Lisbon Psychiatric Hospital Centre, Lisbon, Portugal.ORCID 0000-0002-7829-493X
Fernando RosasDivision of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.
Christopher TimmermannDivision of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.
Robin Carhart-HarrisDivision of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.ORCID 0000-0002-6062-7150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReference to an intrinsic healing mechanism or an 'inner healer' is commonplace amongst psychedelic drug-using cultures. The 'inner healer' refers to the belief that psychedelic compounds, plants or concoctions have an intrinsically regenerative action on the mind and brain, analogous to intrinsic healing mechanisms within the physical body, for example, after sickness or injury.

aimsHere, we sought to test and critique this idea by devising a single subjective rating item pertaining to perceived 'inner healing' effects.

methodsThe item was issued to 59 patients after a single high (25 mg,

resultsInner healer scores were higher after the high versus placebo dose of psilocybin (

conclusionsThe principle of activating inner healing mechanisms via psychedelics is scientifically nascent; however, this study takes a positivist and pragmatic step forward, asking whether it warrants further examination.

Indexed as

HallucinogensPsilocybinAdultDepressionDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedYoung AdultHallucinogensPsilocybinautomaticHealingpsychedelicTelos

Identifiers

PMID38605658
PMCPMC11102647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.