ArticleScientific reports2024
Tuning spatially fractionated radiotherapy dose profiles using the moiré effect.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- The future is not always uniform: rethinking radiotherapy through spatial fractionation.Nature reviews. Clinical oncology · 2026Review
- Impact of collimator misalignments on dosimetric robustness in proton minibeam radiotherapy using an automated measurement setup.Medical physics · 2026Article
- Monte Carlo-based characterization of proton minibeam radiation therapy across clinically relevant beam parameters.Physics and imaging in radiation oncology · 2026Article
- Collimator position optimization for proton minibeam radiation therapy.Scientific reports · 2026Article
- Collimator position optimization for proton minibeam radiation therapy.Research square · 2026Article
- Proton minibeam radiotherapy: a review.Frontiers in oncology · 2025Review
- SFRT combined with immunotherapy for a growing hepatocellular carcinoma after the failure of anti-angiogenesis and anti-PD1 treatment: a case report.Frontiers in oncology · 2025Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Spatially Fractionated Radiotherapy (SFRT) has demonstrated promising potential in cancer treatment, combining the advantages of reduced post-radiation effects and enhanced local control rates. Within this paradigm, proton minibeam radiotherapy (pMBRT) was suggested as a new treatment modality, possibly producing superior normal tissue sparing to conventional proton therapy, leading to improvements in patient outcomes. However, an effective and convenient beam generation method for pMBRT, capable of implementing various optimum dose profiles, is essential for its real-world application. Our study investigates the potential of utilizing the moiré effect in a dual collimator system (DCS) to generate pMBRT dose profiles with the flexibility to modify the center-to-center distance (CTC) of the dose distribution in a technically simple way.We employ the Geant4 Monte Carlo simulations tool to demonstrate that the angle between the two collimators of a DCS can significantly impact the dose profile. Varying the DCS angle from 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.