Trial reportNature communications2024
Multisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges.
Trial report in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04188834 (Neurophysiological and Behavioral Effects of Sensory Flicker and Electrical Flicker Stimulation), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurophysiological and Behavioral Effects of Sensory Flicker and Electrical Flicker Stimulation
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Effects of Family Voice Intervention on Delirium in Adult Critical Care Patients: A Systematic Review and Meta-Analysis.Nursing in critical care · 2025Pooled it
- Rhythmic stimulation elicits multiple, concurrent neural responses.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Audiovisual gamma stimulation restores hippocampal neurogenesis and neural circuit plasticity in aging mice.Molecular psychiatry · 2026Article
- Pre-stimulus alpha power modulates trial-by-trial variability in theta rhythmic multisensory entrainment strength and theta-induced memory effect.Communications psychology · 2026Article
- Light-based 40 Hz sensory therapy for brain disorders: physiological basis, therapeutic mechanisms, and future prospects.Frontiers in medicine · 2026Review
- Audio-Visual Entrainment Neuromodulation: A Review of Technical and Functional Aspects.Brain sciences · 2025Review
- Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice.APL bioengineering · 2025Article
- Visual gamma stimulation induces 40 Hz neural oscillations in the human hippocampus and alters phase synchrony and lag.Communications biology · 2025Article
- VR-based gamma sensory stimulation: a pilot feasibility study.Scientific reports · 2025Article
- 40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rough is salient: a conserved vocal niche to hijack the brain's salience system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Response coupling with an auxiliary neural signal for enhancing brain signal detection.Scientific reports · 2025Article
- Innovations in noninvasive sensory stimulation treatments to combat Alzheimer's disease.PLoS biology · 2025Review
- 40 Hz light stimulation restores early brain dynamics alterations and associative memory in Alzheimer's disease model mice.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity.Journal of neural engineering · 2024Article
- Euterpe music therapy methodology and procedure algorithms.Frontiers in neurology · 2024Article
- 40 Hz audiovisual stimulation improves sustained attention and related brain oscillations.Imaging neuroscience (Cambridge, Mass.)Article
- Dithering suppresses half-harmonic neural synchronisation to photic stimulation in humans.Brain stimulationArticle
Corrections and comments
- Update of
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep brain structures and are practical for chronic daily home use are desirable for a variety of therapeutic applications. Repetitive audio-visual stimulation, or sensory flicker, is an accessible approach that modulates hippocampus in mice, but its effects in humans are poorly defined. We therefore quantified the neurophysiological effects of flicker with high spatiotemporal resolution in patients with focal epilepsy who underwent intracranial seizure monitoring. In this interventional trial (NCT04188834) with a cross-over design, subjects underwent different frequencies of flicker stimulation in the same recording session with the effect of sensory flicker exposure on local field potential (LFP) power and interictal epileptiform discharges (IEDs) as primary and secondary outcomes, respectively. Flicker focally modulated local field potentials in expected canonical sensory cortices but also in the medial temporal lobe and prefrontal cortex, likely via resonance of stimulated long-range circuits. Moreover, flicker decreased interictal epileptiform discharges, a pathological biomarker of epilepsy and degenerative diseases, most strongly in regions where potentials were flicker-modulated, especially the visual cortex and medial temporal lobe. This trial met the scientific goal and is now closed. Our findings reveal how multi-sensory stimulation may modulate cortical structures to mitigate pathological activity in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.