Evidence map›Paper›PMID 38604769›Full record

Trial reportBMJ paediatrics open2024

Clinical and nutritional correlates of bacterial diarrhoea aetiology in young children: a secondary cross-sectional analysis of the ABCD trial.

Sarah Somji, Per Ashorn, Karim Manji, Tahmeed Ahmed, Md Chisti, Usha Dhingra, Sunil Sazawal, Benson Singa, Judd L Walson, Patricia Pavlinac and 13 more

Registry-linked trialOpen access · diamondAbstract readMulticenter StudyRandomized Controlled TrialClinical Trial, Phase III
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ paediatrics open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03130114 (Antibiotics for Children With Severe Diarrhoea), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03130114 phase3completednot on this map

Antibiotics for Children With Severe Diarrhoea

TypeinterventionalSponsorWorld Health OrganizationRan2017 to 2020Enrolled8,268ConditionsDiarrheaArmsAzithromycin, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 14 institutions in 11 countries.

Sarah SomjiCenter for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland sarahsomji@gmail.com.ORCID http://orcid.org/0000-0001-6031-830X
Per AshornCenter for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Karim ManjiDepartment of Pediatrics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, United Republic of.
Tahmeed AhmedDivision of Nutrition and Clinical Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID http://orcid.org/0000-0002-4607-7439
Md ChistiDivision of Nutrition and Clinical Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Usha DhingraCentre for Public Health Kinetics (CPHK), Delhi, India.
Sunil SazawalCentre for Public Health Kinetics (CPHK), Delhi, India.
Benson SingaCentre for Public Health Kinetics (CPHK), Delhi, India.
Judd L WalsonDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID http://orcid.org/0000-0003-4836-720X
Patricia PavlinacDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Naor Bar-ZeevInternational Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Eric HouptDepartment of Medicine, Infectious Diseases, University of Virginia, Charlottesville, Virginia, USA.
Queen DubeDepartment of Pediatrics, Queen Elizabeth Central Hospital, Blantyre, Southern Region, Malawi.
Karen KotloffCenter for Vaccine Development and Global Health, University of Maryland Baltimore, Baltimore, Maryland, USA.
Samba SowCentre pour le Developpement des Vaccins Mali, Bamako, Mali.
Mohammad Tahir YousafzaiDepartment of Pediatrics and Child Heath, The Aga Khan University, Karachi, Sindh, Pakistan.
Farah QamarDepartment of Pediatrics and Child Heath, The Aga Khan University, Karachi, Sindh, Pakistan.
Rajiv BahlDepartment of Maternal, Child, and Adolescent Health and Aging, World Health Organization, Geneva, Switzerland.
Ayesha De CostaDepartment of Maternal, Child, and Adolescent Health and Aging, World Health Organization, Geneva, Switzerland.
Jonathon SimonDepartment of Maternal, Child, and Adolescent Health and Aging, World Health Organization, Geneva, Switzerland.
Christopher R Sudfeld *Department of Global Health and Population and Nutrition, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Christopher P Duggan *Department of Global Health and Population and Nutrition, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
ABCD Study Group
The Centre for Health (New Zealand) · NZWorld Health Organization - Pakistan · PKAga Khan University · PKInternational Centre for Diarrhoeal Disease Research · BDMuhimbili University of Health and Allied Sciences · TZUniversity of Washington · USBoston Children's Hospital · USCentre Pour le Développement des Vaccins-Mali · MLHarvard University · USJohns Hopkins University · USOffice of Infectious Diseases · USQueen Elizabeth Central Hospital · MWTampere University · FIUniversity of Maryland, Baltimore · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561World Health Organization 001
6 · The paper itself

Abstract

objectiveThe objective was to assess the association between nutritional and clinical characteristics and quantitative PCR (qPCR)-diagnosis of bacterial diarrhoea in a multicentre cohort of children under 2 years of age with moderate to severe diarrhoea (MSD).

designA secondary cross-sectional analysis of baseline data collected from the AntiBiotics for Children with Diarrhoea trial (NCT03130114). PATIENTS: Children with MSD (defined as STUDY PERIOD: June 2017-July 2019.

interventionsNone.

main outcome measuresLikely bacterial aetiology of diarrhoea. Secondary outcomes included specific diarrhoea aetiology.

resultsA total of 6692 children with MSD had qPCR results available and 28% had likely bacterial diarrhoea aetiology. Compared with children with severe stunting, children with MAM (adjusted OR (aOR) (95% CI) 1.56 (1.18 to 2.08)), some/severe dehydration (aOR (95% CI) 1.66 (1.25 to 2.22)) or both (aOR (95% CI) 2.21 (1.61 to 3.06)), had higher odds of having likely bacterial diarrhoea aetiology. Similar trends were noted for stable toxin-enterotoxigenic

conclusionThe presence of MAM, dehydration or high stool frequency may be helpful in identifying children with MSD who might benefit from antibiotics.

Indexed as

Bacterial InfectionsDysenteryAnti-Bacterial AgentsChild, PreschoolCross-Sectional StudiesDehydrationDiarrheaGrowth DisordersHumansInfantInfant, NewbornAnti-Bacterial Agentsepidemiologyinfant

Identifiers

PMID38604769
PMCPMC11015214
OpenAlexW4394727937

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.