Evidence map›Paper›PMID 38603983›Full record

ArticlePediatric neurology2024

Measurement of Developmental and Behavioral Concerns in Toddlers With Tuberous Sclerosis Complex.

Nicole M McDonald, Sydney Jacobs, Carly Hyde, Connie Kasari, Shafali S Jeste

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicole M McDonaldUCLA Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, California. Electronic address: nmcdonald@mednet.ucla.edu.
Sydney JacobsDepartment of Neurology, Children's Hospital Los Angeles, Los Angeles, California.
Carly HydeUCLA Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, California.
Connie KasariUCLA Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, California.
Shafali S JesteDepartment of Neurology, Children's Hospital Los Angeles, Los Angeles, California.
Children's Hospital of Los Angeles · US

Funding

Mechanisms of Change with Early Intervention in Tuberous Sclerosis ComplexR01HD090138 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESTE, SHAFALI SPURLING · 2017 to 2022
$3.1M
NICHD NIH HHS R01 HD090138
6 · The paper itself

Abstract

backgroundThe TAND (Tuberous Sclerosis Complex [TSC]-Associated Neuropsychiatric Disorders) Checklist was developed as a clinical screener for neurodevelopmental disorders in TSC. Most studies have described patterns in older children and adults. This study sought to better understand behavioral concerns as measured by the TAND Checklist in young children with TSC.

methodsWe examined patterns of caregiver responses to the TAND Checklist in 90 toddlers with TSC (12 to 23 months n = 60; 24 to 36 months n = 30) through data collected during baseline visits across two TSC early intervention studies.

resultsOver 90% of caregivers reported at least one behavioral concern related to TAND. The number of concerns increased with age. Delayed language was the most frequently reported concern across ages (12 to 23 months: 58.3%, 24 to 36 months: 86.7%). Questions related to behavioral concerns were largely relevant in this age range, but questions in other areas, such as neuropsychological or academic function, were not.

conclusionsTAND symptoms are very common in toddlers with TSC, and these symptoms may increase with age. The TAND Checklist is a useful tool for identifying behavioral concerns efficiently, but several items and sections are not suited to younger children. Results support the development of an abbreviated form of the TAND Checklist for toddlers.

Indexed as

ChecklistTuberous SclerosisChild, PreschoolDevelopmental DisabilitiesFemaleHumansInfantMaleBehavioral concernsTANDTAND ChecklistToddlersTSC-Associated Neuropsychiatric DisordersTuberous sclerosis complex

Identifiers

PMID38603983
PMCPMC11143920
OpenAlexW4393098530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.