ArticleCell reports2024
Specific connectivity optimizes learning in thalamocortical loops.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Corticothalamic communication for action coordination in a skilled motor behavior.Nature neuroscience · 2026Article
- The potential of laminar functional MRI in refining the understanding of epilepsy in humans.Brain : a journal of neurology · 2025Review
- Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility.Nature communications · 2025Article
- A corticostriatal learning mechanism linking excess striatal dopamine and auditory hallucinations.bioRxiv : the preprint server for biology · 2025Article
- Discovering plasticity rules that organize and maintain neural circuits.bioRxiv : the preprint server for biology · 2024Article
- Thalamocortical architectures for flexible cognition and efficient learning.Trends in cognitive sciences · 2024Review
- Cerebellar contributions across behavioural timescales: a review from the perspective of cerebro-cerebellar interactions.Frontiers in systems neuroscience · 2023Review
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Authors and funding
7 authors.
Funding
Abstract
Thalamocortical loops have a central role in cognition and motor control, but precisely how they contribute to these processes is unclear. Recent studies showing evidence of plasticity in thalamocortical synapses indicate a role for the thalamus in shaping cortical dynamics through learning. Since signals undergo a compression from the cortex to the thalamus, we hypothesized that the computational role of the thalamus depends critically on the structure of corticothalamic connectivity. To test this, we identified the optimal corticothalamic structure that promotes biologically plausible learning in thalamocortical synapses. We found that corticothalamic projections specialized to communicate an efference copy of the cortical output benefit motor control, while communicating the modes of highest variance is optimal for working memory tasks. We analyzed neural recordings from mice performing grasping and delayed discrimination tasks and found corticothalamic communication consistent with these predictions. These results suggest that the thalamus orchestrates cortical dynamics in a functionally precise manner through structured connectivity.
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Registered trials
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