Evidence map›Paper›PMID 38602833›Full record

Trial reportEnvironmental health perspectives2024

Influence of Temperature and Precipitation on the Effectiveness of Water, Sanitation, and Handwashing Interventions against Childhood Diarrheal Disease in Rural Bangladesh: A Reanalysis of the WASH Benefits Bangladesh Trial.

Anna T Nguyen, Jessica A Grembi, Marie Riviere, Gabriella Barratt Heitmann, William D Hutson, Tejas S Athni, Arusha Patil, Ayse Ercumen, Audrie Lin, Yoshika Crider and 6 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Environmental health perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Waterborne diseases and climate change.Nature reviews. Microbiology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Associations between floor material andbioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Anna T NguyenDepartment of Epidemiology and Population Health, Stanford University, Stanford, California, USA.ORCID 0000-0002-2211-9040
Jessica A GrembiDivision of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA.
Marie RiviereDepartment of Epidemiology and Population Health, Stanford University, Stanford, California, USA.
Gabriella Barratt HeitmannDepartment of Epidemiology and Population Health, Stanford University, Stanford, California, USA.
William D HutsonBrown School, Washington University in St. Louis, St. Louis, Missouri, USA.
Tejas S AthniDepartment of Epidemiology and Population Health, Stanford University, Stanford, California, USA.
Arusha PatilDepartment of Epidemiology and Population Health, Stanford University, Stanford, California, USA.
Ayse ErcumenDepartment of Forestry and Environmental Resources, North Carolina State University, Raleigh, North Carolina, USA.
Audrie LinDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Yoshika CriderKing Center on Global Development, Stanford University, Stanford, California, USA.
Andrew MertensDivision of Epidemiology and Biostatistics, University of California, Berkeley, Berkeley, California, USA.
Leanne UnicombEnvironmental Health and WASH, Health System and Population Studies Division, ICDDR,B, Dhaka, Bangladesh.
Mahbubur RahmanEnvironmental Health and WASH, Health System and Population Studies Division, ICDDR,B, Dhaka, Bangladesh.
Stephen P LubyDivision of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA.
Benjamin F ArnoldFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
Jade Benjamin-ChungDepartment of Epidemiology and Population Health, Stanford University, Stanford, California, USA.

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Serologic measures of enteric pathogen transmission for intervention studies and population monitoring in low-resource settingsR01AI166671 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Benjamin F Arnold · 2022 to 2026
$2.7M
Stanford BSSR Pre-Doctoral Training Program at the Intersection of Data Sciences with Behavioral, Social, and Population Health ResearchT32HL151323 · NHLBI · STANFORD UNIVERSITY · PI Michelle Christina Odden, David H Rehkopf · 2020 to 2026
$1.6M
Measuring spillover effects of reactive, focal malaria elimination interventionsK01AI141616 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BENJAMIN-CHUNG, JADE · 2019 to 2022
$601k
Towards a mechanistic understanding of the role of gut microbiota in postnatal growth impairmentF32DK130574 · NIDDK · STANFORD UNIVERSITY · PI GREMBI, JESSICA A. · 2022 to 2024
$171k
NHLBI NIH HHS T32 HL151323NIAID NIH HHS K01 AI141616NIAID NIH HHS R01 AI166671NIDDK NIH HHS F32 DK130574NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

backgroundDiarrheal disease is a leading cause of childhood morbidity and mortality globally. Household water, sanitation, and handwashing (WASH) interventions can reduce exposure to diarrhea-causing pathogens, but meteorological factors may impact their effectiveness. Information about effect heterogeneity under different weather conditions is critical to refining these targeted interventions.

objectivesWe aimed to determine whether temperature and precipitation modified the effect of low-cost, point-of-use WASH interventions on child diarrhea.

methodsWe analyzed data from a trial in rural Bangladesh that compared child diarrhea prevalence between clusters (

resultsGenerally, WASH interventions most effectively prevented diarrhea during monsoon season, particularly following weeks with heavy rain or high temperatures. The PR for diarrhea in the WASH interventions group compared with the control group was 0.49 (95% CI: 0.35, 0.68) after 1 d of heavy rainfall, with a less-protective effect [ DISCUSSION: WASH intervention effectiveness was strongly influenced by precipitation and temperature, and nearly all protective effects were observed during the rainy season. Future implementation of these interventions should consider local environmental conditions to maximize effectiveness, including targeted efforts to maintain latrines and promote community adoption ahead of monsoon seasons. https://doi.org/10.1289/EHP13807.

Indexed as

SanitationWaterBangladeshChildDiarrheaHand DisinfectionHumansSouth Asian PeopleTemperatureWater

Identifiers

PMID38602833
PMCPMC11008709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.