Evidence map›Paper›PMID 38602654›Full record

ArticleMolecular neurobiology2024

Based on Virtual Screening and Simulation Exploring the Mechanism of Plant-Derived Compounds with PINK1 to Postherpetic Neuralgia.

Wenjing Guo, Bo Zhang, Minchen Liu, Jiquan Zhang, Yi Feng

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wenjing GuoEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Shanghai, 201203, People's Republic of China.
Bo ZhangEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Shanghai, 201203, People's Republic of China.
Minchen LiuEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Shanghai, 201203, People's Republic of China.
Jiquan ZhangEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Shanghai, 201203, People's Republic of China. 13816062506@139.com.
Yi FengEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Shanghai, 201203, People's Republic of China. fyi@vip.sina.com.ORCID http://orcid.org/0009-0000-0289-6718

Funding

Science and Technology Commission of Shanghai Municipality 23S21900300Shanghai Municipal Commission of Health and Family Planning ZY(2021-2023)-0208Shanghai Science and Technology Commission 14401901400
6 · The paper itself

Abstract

Accumulating evidence strongly supports that PINK1 mutation can mediate mitochondrial autophagy dysfunction in dopaminergic neurons. This study was conducted to determine the role of PINK1 in the pathogenesis of postherpetic neuralgia (PHN) and find new targets for its treatment. A rigorous literature review was conducted to identify 2801 compounds from more than 200 plants in Asia. Virtual screening was used to shortlist the compounds into 20 groups based on their binding energies. MM/PBSA was used to further screen the compound dataset, and vitexin, luteoloside, and 2'-deoxyadenosine-5'-monophosphate were found to have a score of - 59.439, - 52.421, and - 47.544 kcal/mol, respectively. Pain behavioral quantification, enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, western blotting, and transmission electron microscopy were used to confirm the effective mechanism. Vitexin had the most significant therapeutic effect on rats with PHN followed by luteoloside; 2'-deoxyadenosine-5'-monophosphate had no significant effect. Our findings suggested that vitexin could alleviate PHN by regulating mitochondrial autophagy through PINK1.

Indexed as

Neuralgia, PostherpeticProtein KinasesAnimalsApigeninAutophagyDrug Evaluation, PreclinicalMaleMitochondriaMolecular Docking SimulationPlant ExtractsPTEN-Induced Putative KinaseRatsRats, Sprague-DawleyApigeninPlant ExtractsProtein KinasesPTEN-Induced Putative Kinasevitexin2′-Deoxyadenosine-5′-monophosphateLuteolosidePINK1Postherpetic neuralgiaVitexin

Identifiers

PMID38602654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.