Evidence map›Paper›PMID 38602492›Full record

ArticleACS chemical biology2024

Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.

Nataliia V Machushynets, Karol Al Ayed, Barbara R Terlouw, Chao Du, Ned P Buijs, Joost Willemse, Somayah S Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren and 6 more

Abstract read
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Exploring the Chemical Space ofOrganic letters · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nataliia V MachushynetsMolecular Biotechnology, Institute of Biology, Leiden University, Leiden 2333 BE, The Netherlands.ORCID 0000-0002-8530-1966
Karol Al AyedBiological Chemistry Group, Institute of Biology, Leiden University, Leiden 2333 BE, The Netherlands.
Barbara R TerlouwBioinformatics Group, Wageningen University, Wageningen 6700 PB, The Netherlands.
Chao DuMolecular Biotechnology, Institute of Biology, Leiden University, Leiden 2333 BE, The Netherlands.ORCID 0000-0003-3447-5293
Ned P BuijsBiological Chemistry Group, Institute of Biology, Leiden University, Leiden 2333 BE, The Netherlands.
Joost WillemseMolecular Biotechnology, Institute of Biology, Leiden University, Leiden 2333 BE, The Netherlands.
Somayah S ElsayedMolecular Biotechnology, Institute of Biology, Leiden University, Leiden 2333 BE, The Netherlands.ORCID 0000-0003-3837-6137
Julian SchillBioVersys AG, c/o Technologiepark, Basel CH-4057, Switzerland.
Vincent TreboscBioVersys AG, c/o Technologiepark, Basel CH-4057, Switzerland.
Michel PierenBioVersys AG, c/o Technologiepark, Basel CH-4057, Switzerland.
Francesca M AlexanderSchool of Chemistry and Chemical Engineering, Queen's University of Belfast, Belfast BT9 5AG, United Kingdom.ORCID 0000-0002-4218-0965
Stephen A CochraneSchool of Chemistry and Chemical Engineering, Queen's University of Belfast, Belfast BT9 5AG, United Kingdom.ORCID 0000-0002-6239-6915
Mark R LilesDepartment of Biological Sciences, Auburn University, Auburn, Alabama 36849, United States.ORCID 0000-0002-9313-8150
Marnix H MedemaBioinformatics Group, Wageningen University, Wageningen 6700 PB, The Netherlands.ORCID 0000-0002-2191-2821
Nathaniel I MartinBiological Chemistry Group, Institute of Biology, Leiden University, Leiden 2333 BE, The Netherlands.ORCID 0000-0001-8246-3006
Gilles P van WezelMolecular Biotechnology, Institute of Biology, Leiden University, Leiden 2333 BE, The Netherlands.ORCID 0000-0003-0341-1561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of multidrug-resistant (MDR) pathogens combined with a decline in antibiotic discovery presents a major challenge for health care. To refill the discovery pipeline, we need to find new ways to uncover new chemical entities. Here, we report the global genome mining-guided discovery of new lipopeptide antibiotics tridecaptin A

Indexed as

Anti-Bacterial AgentsMicrobial Sensitivity TestsPseudomonas aeruginosaDrug DiscoveryHost SpecificityHumansLipopeptidesPeptidesAnti-Bacterial AgentsLipopeptidesPeptidestridecaptins

Identifiers

PMID38602492
PMCPMC11106739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.