Evidence map›Paper›PMID 38602171›Full record

ReviewPediatric transplantation2024

Antibody-mediated rejection in pediatric kidney transplant recipients: A report from the Pediatric Nephrology Research Consortium.

Isa F Ashoor, Rachel M Engen, Dechu Puliyanda, Nicole Hayde, Caitlin G Peterson, Rima S Zahr, Sonia Solomon, Mahmoud Kallash, Rouba Garro, Amrish Jain and 5 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Tailoring HLA antibody monitoring post-transplantation.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 14 institutions in 1 country.

Isa F AshoorDepartment of Pediatrics, Harvard Medical School and Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-0539-4021
Rachel M EngenDepartment of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin, USA.ORCID 0000-0002-0584-7951
Dechu PuliyandaDepartment of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-6988-8533
Nicole HaydeDepartment of Pediatrics, Children's Hospital at Montefiore, Bronx, New York, USA.ORCID 0000-0003-0519-7271
Caitlin G PetersonDivision of Pediatric Nephrology and Hypertension, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-7208-6574
Rima S ZahrDepartment of Pediatrics, Division of Pediatric Nephrology and Hypertension, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Sonia SolomonDepartment of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Boston Children's Health Physicians, Valhalla, New York, USA.ORCID 0000-0002-2636-6647
Mahmoud KallashDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Rouba GarroDepartment of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Amrish JainDepartment of Pediatrics, Central Michigan University and Children's Hospital of Michigan, Detroit, Michigan, USA.
Lyndsay A HarshmanStead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0003-4952-8132
Scott T McEwenDivision of Pediatric Nephrology, University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota, USA.ORCID 0000-0003-0003-5812
Asifhusen MansuriDepartment of Pediatrics, Children's Hospital of Georgia, Augusta University, Augusta, Georgia, USA.
Mathew J GregoskiDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Katherine E TwombleyDepartment of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-2073-2834
Medical University of South Carolina · USAugusta University · USBoston Children's Hospital · USCedars-Sinai Medical Center · USCentral Michigan University · USChildren's Hospital at Montefiore · USEmory University · USNationwide Children's Hospital · USNew York Medical College · USUniversity of Iowa · USUniversity of Minnesota Children's Hospital · USUniversity of Tennessee Health Science Center · USUniversity of Utah · USUniversity of Wisconsin–Madison · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
NCATS NIH HHS UL1 TR001450
6 · The paper itself

Abstract

backgroundAntibody-mediated rejection (AMR) is a major cause of kidney allograft loss. There is a paucity of large-scale pediatric-specific data regarding AMR treatment outcomes.

methodsData were obtained from 14 centers within the Pediatric Nephrology Research Consortium. Kidney transplant recipients aged 1-18 years at transplant with biopsy-proven AMR between 2009 and 2019 and at least 12 months of follow-up were included. The primary outcome was graft failure or an eGFR <20 mL/min/1.73 m

resultsWe reviewed 123 AMR episodes. Median age at diagnosis was 15 years at a median 22 months post-transplant. The primary outcome developed in 27.6%. eGFR <30 m/min/1.73 m

conclusionsIn this large cohort of pediatric kidney transplant recipients with AMR, nearly one-third of patients experienced graft failure or significant graft dysfunction within 12 months of diagnosis. Poor graft function at time of diagnosis was associated with higher odds of graft failure.

Indexed as

Kidney TransplantationNephrologyAdolescentChildGraft RejectionGraft SurvivalHumansIsoantibodiesKidneyTransplant RecipientsIsoantibodiesantibody‐mediated rejectionkidney transplantpediatrics

Identifiers

PMID38602171
PMCPMC11013566
OpenAlexW4394725898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.