Evidence map›Paper›PMID 38602101›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2024

Arterial Smooth Muscle Cell AKAP150 Mediates Exercise-Induced Repression of Ca

Yanyan Zhang, Zhaoxia Xu, Meiling Shan, Jiaqi Cao, Yang Zhou, Yu Chen, Lijun Shi

Abstract read
PubMed Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. CaInflammation and regeneration · 2025
    Review
  2. Review
  3. CaInflammation and regeneration · 2024
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yanyan ZhangDepartment of Exercise Physiology (Y. Zhang, Z.X., M.S., J.C., Y. Zhou, Y.C., L.S.), Beijing Sport University, China.ORCID 0009-0000-8147-3659
Zhaoxia XuDepartment of Exercise Physiology (Y. Zhang, Z.X., M.S., J.C., Y. Zhou, Y.C., L.S.), Beijing Sport University, China.ORCID 0009-0002-6290-8666
Meiling ShanDepartment of Exercise Physiology (Y. Zhang, Z.X., M.S., J.C., Y. Zhou, Y.C., L.S.), Beijing Sport University, China.ORCID 0009-0003-6278-4429
Jiaqi CaoDepartment of Exercise Physiology (Y. Zhang, Z.X., M.S., J.C., Y. Zhou, Y.C., L.S.), Beijing Sport University, China.ORCID 0009-0000-2973-0515
Yang ZhouDepartment of Exercise Physiology (Y. Zhang, Z.X., M.S., J.C., Y. Zhou, Y.C., L.S.), Beijing Sport University, China.ORCID 0009-0006-8151-4776
Yu ChenDepartment of Exercise Physiology (Y. Zhang, Z.X., M.S., J.C., Y. Zhou, Y.C., L.S.), Beijing Sport University, China.
Lijun ShiDepartment of Exercise Physiology (Y. Zhang, Z.X., M.S., J.C., Y. Zhou, Y.C., L.S.), Beijing Sport University, China.ORCID 0000-0001-6655-2949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension is a major, prevalent risk factor for the development and progression of cerebrovascular disease. Regular exercise has been recommended as an excellent choice for the large population of individuals with mild-to-moderate elevations in blood pressure, but the mechanisms that underlie its vascular-protective and antihypertensive effects remain unknown. Here, we describe a mechanism by which myocyte AKAP150 (A-kinase anchoring protein 150) inhibition induced by exercise training alleviates voltage-dependent L-type Ca

methodsSpontaneously hypertensive rats and newly generated smooth muscle-specific AKAP150 knockin mice were used to assess the role of myocyte AKAP150/Ca

resultsActivation of the AKAP150/PKCα (protein kinase Cα) signaling increased Ca

conclusionsThe current study demonstrates that aerobic exercise ameliorates Ca

Indexed as

A Kinase Anchor ProteinsCalcium Channels, L-TypeCerebral ArteriesDisease Models, AnimalHypertensionMuscle, Smooth, VascularMyocytes, Smooth MuscleRats, Inbred SHRAngiotensin IIAnimalsBlood PressureCalcium SignalingMaleMiceMice, Inbred C57BLPhysical Conditioning, AnimalAkap5 protein, mouseAkap5 protein, ratA Kinase Anchor ProteinsAngiotensin IICACNA1C protein, mouseCacna1c protein, ratCalcium Channels, L-TypeProtein Kinase C-alphaaerobicAKAP150cerebral arteriesexercisehypertension

Identifiers

PMID38602101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.