Evidence map›Paper›PMID 38602089›Full record

Observational studyInternational journal of dermatology2024

Observational pilot study of multi-wavelength wearable light dosimetry for erythropoietic protoporphyria.

Amy K Dickey, Jaime Berkovich, Rebecca K Leaf, Paul Y Jiang, Gisela Lopez-Galmiche, Lina Rebeiz, Kristen Wheeden, Irene Kochevar, William Savage, Sophia Zhao and 7 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Amy K DickeyDepartment of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0003-2979-9664
Jaime BerkovichWearifi, Inc., Evanston, IL, USA.
Rebecca K LeafDepartment of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
Paul Y JiangDepartment of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0002-2016-6556
Gisela Lopez-GalmicheNeurolux Inc., Evanston, IL, USA.
Lina RebeizDepartment of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kristen WheedenUnited Porphyrias Association, Bethesda, MD, USA.
Irene KochevarHarvard Medical School, Boston, MA, USA.
William SavageDisc Medicine, Watertown, MA, USA.
Sophia ZhaoAnalytica Now LLC, Brookline, MA, USA.
Elizabeth CampisiWearifi, Inc., Evanston, IL, USA.
Seung Y HeoQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Jacob TruebWearifi, Inc., Evanston, IL, USA.
Ethan P M LaRochelleQUEL Imaging, Hartford, VT, USA.
John RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Anthony BanksWearifi, Inc., Evanston, IL, USA.
Jan-Kai ChangWearifi, Inc., Evanston, IL, USA.

Funding

Porphyrias Consortium: SupplementU54DK083909 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DESNICK, ROBERT J · 2009 to 2023
$18.5M
The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
Measuring and Understanding Light Sensitivity in Erythropoietic ProtoporphyriaK23AR079586 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI YEUNG, AMY KATHRYN · 2021 to 2025
$875k
National Center for Advancing Translational Sciences (NCATS)National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)National Institutes of Health (NIH) U54DK083909NIAMS NIH HHS 1K23AR079586NIAMS NIH HHS K23 AR079586NIBIB NIH HHS P41 EB031772NIDDK NIH HHS U54 DK083909
6 · The paper itself

Abstract

backgroundErythropoietic protoporphyria (EPP) causes painful light sensitivity, limiting quality of life. Our objective was to develop and validate a wearable light exposure device and correlate measurements with light sensitivity in EPP to predict and prevent symptoms.

methodsA wearable light dosimeter was developed to capture light doses of UVA, blue, and red wavelengths. A prospective observational pilot study was performed in which five EPP patients wore two light dosimeters for 3 weeks, one as a watch, and one as a shirt clip.

resultsStandard deviation (SD) increases from the mean in the daily blue light dose increased the odds ratio (OR) for symptom risk more than the self-reported outdoor time (OR 2.76 vs. 2.38) or other wavelengths, and a one SD increase from the mean in the daily blue light wristband device dose increased the OR for symptom risk more than the daily blue light shirt clip (OR 2.45 vs. 1.62). The area under the receiver operator curve for the blue light wristband dose was 0.78, suggesting 78% predictive accuracy.

conclusionThese data demonstrate that wearable blue light dosimetry worn as a wristband is a promising method for measuring light exposure and predicting and preventing symptoms in EPP.

Indexed as

Protoporphyria, ErythropoieticWearable Electronic DevicesAdultFemaleHumansLightMaleMiddle AgedPilot ProjectsProspective StudiesRadiation DosimetersUltraviolet Raysblue lighterythropoietic protoporphyrialight dosimetrylight sensitivityphotosensitivityprotoporphyriawearable technology

Identifiers

PMID38602089
PMCPMC11467130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.