Evidence map›Paper›PMID 38602002›Full record

ArticleActa biochimica et biophysica Sinica2024

CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway.

Caixia Liu, Jinmei Wang, Yurong Tan, Chi Liu, Xiangping Qu, Huijun Liu, Meiling Tan, Changqing Deng, Xiaoqun Qin, Yang Xiang

Abstract read
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In one paragraph

Article in Acta biochimica et biophysica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caixia LiuKey Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha 410208, China.
Jinmei WangSchool of Basic Medicine, Central South University, Changsha 410078, China.
Yurong TanSchool of Basic Medicine, Central South University, Changsha 410078, China.
Chi LiuSchool of Basic Medicine, Central South University, Changsha 410078, China.
Xiangping QuSchool of Basic Medicine, Central South University, Changsha 410078, China.
Huijun LiuSchool of Basic Medicine, Central South University, Changsha 410078, China.
Meiling TanSchool of Basic Medicine, Central South University, Changsha 410078, China.
Changqing DengKey Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha 410208, China.
Xiaoqun QinSchool of Basic Medicine, Central South University, Changsha 410078, China.
Yang XiangSchool of Basic Medicine, Central South University, Changsha 410078, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adhesion molecules play critical roles in maintaining the structural integrity of the airway epithelium in airways under stress. Previously, we reported that catenin alpha-like 1 (CTNNAL1) is downregulated in an asthma animal model and upregulated at the edge of human bronchial epithelial cells (HBECs) after ozone stress. In this work, we explore the potential role of CTNNAL1 in the structural adhesion of HBECs and its possible mechanism. We construct a CTNNAL1

Indexed as

BronchiEpithelial CellsrhoA GTP-Binding Proteinrho-Associated KinasesSignal Transductionalpha CateninAnimalsCell AdhesionCell LineCell ProliferationHumansMiceOzonealpha CateninCTNNAL1 protein, mouseOzonerhoA GTP-Binding ProteinRhoA protein, mouserho-Associated KinasesROCK1 protein, humanRock1 protein, mouseCTNNAL1human bronchial epithelial cellsozoneRhoA/ROCK1structural integrity

Identifiers

PMID38602002
PMCPMC11177105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.