Evidence map›Paper›PMID 38601986›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age.

Alison Xiaoqiao Xie, Nao Iguchi, Anna P Malykhina

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alison Xiaoqiao XieDivision of Urology, Department of SurgeryUniversity of Colorado Anschutz Medical CampusAuroraColoradoUnited States.ORCID 0000-0003-4395-8510
Nao IguchiDivision of Urology, Department of SurgeryUniversity of Colorado Anschutz Medical CampusAuroraColoradoUnited States.ORCID 0000-0001-6244-7404
Anna P MalykhinaDivision of Urology, Department of SurgeryUniversity of Colorado Anschutz Medical CampusAuroraColoradoUnited States.ORCID 0000-0002-9271-3096
University of Colorado Anschutz Medical Campus · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
ZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1M
Activating Peripheral Glia to Relieve Visceral Pain in Animal Models of Urological Chronic Pelvic Pain Syndrome (UCPPS)R01DK129260 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI XIE, XIAOQIAO · 2021 to 2025
$1.7M
Role of Mechanotransduction in detrusor over activityR01DK095817 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MALYKHINA, ANNA P · 2014 to 2017
$1.2M
Regulation of pelvic pain and micturition reflex by VEGF in urological chronic pelvic pain syndromeR01DK121506 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MALYKHINA, ANNA P · 2019 to 2021
$700k
NCATS NIH HHS UL1 TR001082NIDDK NIH HHS R01 DK095817NIDDK NIH HHS R01 DK121506NIDDK NIH HHS R01 DK129260NINDS NIH HHS P30 NS048154
6 · The paper itself

Abstract

Stretch-activated two-pore domain K

Indexed as

HypertrophyMice, KnockoutMuscle ContractionMuscle, SmoothPotassium Channels, Tandem Pore DomainUrinary BladderAge FactorsAgingAnimalsFemaleMaleMiceMice, Inbred C57BLUrinationpotassium channel protein TREK-1Potassium Channels, Tandem Pore Domainsmooth muscle contractilitytwo-pore domain potassium channelsurinary bladdervoiding dysfunction

Identifiers

PMID38601986
PMCPMC11386977
OpenAlexW4394735214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.