Evidence map›Paper›PMID 38601739›Full record

ArticleFrontiers in cellular and infection microbiology2024

SARS-CoV-2-specific mucosal immune response in vaccinated versus infected children.

Maria Giulia Conti, Eva Piano Mortari, Raffaella Nenna, Alessandra Pierangeli, Leonardo Sorrentino, Federica Frasca, Laura Petrarca, Enrica Mancino, Greta Di Mattia, Luigi Matera and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  6. A novel and safe SmartCapFrontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Maria Giulia ContiDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Eva Piano MortariB Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Raffaella NennaDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Alessandra PierangeliLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Leonardo SorrentinoLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Federica FrascaLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Laura PetrarcaDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Enrica MancinoDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Greta Di MattiaDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Luigi MateraDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Matteo FracellaLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Christian AlbanoB Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Carolina ScagnolariLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Martina CapponiDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Bianca CinicolaDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Rita CarsettiB Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Fabio MidullaDepartment of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The anti-COVID-19 intramuscular vaccination induces a strong systemic but a weak mucosal immune response in adults. Little is known about the mucosal immune response in children infected or vaccinated against SARS-CoV-2. We found that 28% of children had detectable salivary IgA against SARS-CoV-2 even before vaccination, suggesting that, in children, SARS-CoV-2 infection may be undiagnosed. After vaccination, only receptor-binding domain (RBD)-specific IgA1 significantly increased in the saliva. Conversely, infected children had significantly higher salivary RBD-IgA2 compared to IgA1, indicating that infection more than vaccination induces a specific mucosal immune response in children. Future efforts should focus on development of vaccine technologies that also activate mucosal immunity.

Indexed as

COVID-19Immunity, MucosalAdultAntibodies, ViralChildHumansImmunoglobulin AMucous MembraneSARS-CoV-2VaccinationAntibodies, ViralImmunoglobulin AchildrenCOVID-19 vaccinesimmunogenicitymucosal immunitySARS-CoV-2

Identifiers

PMID38601739
PMCPMC11004290
OpenAlexW4393229461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.