Evidence map›Paper›PMID 38601667›Full record

ArticleHeliyon2024

Osteogenic differentiation of human mesenchymal stem cells on electroactive substrates.

M N Tamaño-Machiavello, E O Carvalho, D Correia, L Cordón, S Lanceros-Méndez, A Sempere, R Sabater I Serra, J L Gómez Ribelles

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

M N Tamaño-MachiavelloCentre for Biomaterials and Tissue Engineering, CBIT, Universitat Politècnica de València, 46022 València, Spain.
E O CarvalhoCentre of Physics, Universidade do Minho, 4710-057, Braga, Portugal.
D CorreiaCentre of Chemistry, University of Minho, 4710-057, Braga, Portugal.
L CordónHematology Research Group, Instituto de Investigación Sanitaria La Fe, València, Spain.
S Lanceros-MéndezCentre of Physics, Universidade do Minho, 4710-057, Braga, Portugal.
A SempereHematology Research Group, Instituto de Investigación Sanitaria La Fe, València, Spain.
R Sabater I SerraCentre for Biomaterials and Tissue Engineering, CBIT, Universitat Politècnica de València, 46022 València, Spain.
J L Gómez RibellesCentre for Biomaterials and Tissue Engineering, CBIT, Universitat Politècnica de València, 46022 València, Spain.
Centro de Investigación Biomédica en Red de Cáncer · ESUniversitat Politècnica de València · ESUniversity of Minho · PTBasque Center for Materials, Applications and Nanostructures · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the effect of electroactivity and electrical charge distribution on the biological response of human bone marrow stem cells (hBMSCs) cultured in monolayer on flat poly(vinylidene fluoride), PVDF, substrates. Differences in cell behaviour, including proliferation, expression of multipotency markers CD90, CD105 and CD73, and expression of genes characteristic of different mesenchymal lineages, were observed both during expansion in basal medium before reaching confluence and in confluent cultures in osteogenic induction medium. The crystallisation of PVDF in the electrically neutral α-phase or in the electroactive phase β, both unpoled and poled, has been found to have an important influence on the biological response. In addition, the presence of a permanent positive or negative surface electrical charge distribution in phase β substrates has also shown a significant effect on cell behaviour.

Indexed as

Electroactive cell substratesHuman bone marrow mesenchymal cellsMultipotency markerspoly(vinylidene fluoride)

Identifiers

PMID38601667
PMCPMC11004758
OpenAlexW4393313626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.