Evidence map›Paper›PMID 38601161›Full record

ArticleFrontiers in immunology2024

Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential.

Jasper Nörenberg, Péter Vida, Isabell Bösmeier, Barbara Forró, Anna Nörenberg, Ágnes Buda, Diana Simon, Szabina Erdő-Bonyár, Pál Jáksó, Kálmán Kovács and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Placenta as an Immunological Environment.British journal of biomedical science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Jasper NörenbergDepartment of Medical Microbiology and Immunology, University of Pécs Medical School, Clinical Center, Pécs, Hungary.
Péter VidaDepartment of Obstetrics and Gynaecology, University of Pécs Medical School, Clinical Center, Pécs, Hungary.
Isabell BösmeierDepartment of Medical Microbiology and Immunology, University of Pécs Medical School, Clinical Center, Pécs, Hungary.
Barbara ForróDepartment of Pathology, University of Pécs Medical School, Clinical Center, Pécs, Hungary.
Anna NörenbergNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Ágnes BudaDepartment of Obstetrics and Gynaecology, University of Pécs Medical School, Clinical Center, Pécs, Hungary.
Diana SimonNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Szabina Erdő-BonyárNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Pál JáksóDepartment of Pathology, University of Pécs Medical School, Clinical Center, Pécs, Hungary.
Kálmán KovácsNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Éva MikóDepartment of Medical Microbiology and Immunology, University of Pécs Medical School, Clinical Center, Pécs, Hungary.
Tímea BerkiNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Emese MezősiNational Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary.
Alíz BarakonyiDepartment of Medical Microbiology and Immunology, University of Pécs Medical School, Clinical Center, Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During pregnancy, the maternal immune system must allow and support the growth of the developing placenta while maintaining the integrity of the mother's body. The trophoblast's unique HLA signature is a key factor in this physiological process. This study focuses on decidual γδT cell populations and examines their expression of receptors that bind to non-classical HLA molecules, HLA-E and HLA-G. We demonstrate that decidual γδT cell subsets, including Vδ1, Vδ2, and double-negative (DN) Vδ1-/Vδ2- cells express HLA-specific regulatory receptors, such as NKG2C, NKG2A, ILT2, and KIR2DL4, each with varying dominance. Furthermore, decidual γδT cells produce cytokines (G-CSF, FGF2) and cytotoxic mediators (Granulysin, IFN-γ), suggesting functions in placental growth and pathogen defense. However, these processes seem to be controlled by factors other than trophoblast-derived non-classical HLA molecules. These findings indicate that decidual γδT cells have the potential to actively contribute to the maintenance of healthy human pregnancy.

Indexed as

Antineoplastic AgentsPlacentaCytokinesDeciduaFemaleHLA-G AntigensHumansPregnancyTrophoblastsAntineoplastic AgentsCytokinesHLA-G Antigensangiogenic factorscytokinescytotoxic mediatorsdeciduaHLA-EHLA-GNK receptorsγδT cells

Identifiers

PMID38601161
PMCPMC11004470
OpenAlexW4393231342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.