Evidence map›Paper›PMID 38600956›Full record

ReviewGlomerular diseases

Challenges and Opportunities for the Clinical Translation of Spatial Transcriptomics Technologies.

Kelly D Smith, David K Prince, James W MacDonald, Theo K Bammler, Shreeram Akilesh

Abstract readReview
In one paragraph

Review in Glomerular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
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  19. Computer Vision Methods for Spatial Transcriptomics: A Survey.bioRxiv : the preprint server for biology · 2025
    Article
  20. Rigor and Reproducibility of Spatial Transcriptomics Performed on Clinically Sourced Human Tissues.Laboratory investigation; a journal of technical methods and pathology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelly D SmithDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
David K PrinceKidney Research Institute, Seattle, WA, USA.
James W MacDonaldDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Theo K BammlerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Shreeram AkileshDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Mechanisms of Kidney Injury in COVID-19R01DK130386 · NIDDK · UNIVERSITY OF WASHINGTON · PI AKILESH, SHREERAM, FREEDMAN, BENJAMIN SOLOMON · 2021 to 2023
$1.2M
NCI NIH HHS P30 CA015704NIDDK NIH HHS R01 DK130386NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

Background: The first spatially resolved transcriptomics platforms, GeoMx (Nanostring) and Visium (10x Genomics) were launched in 2019 and were recognized as the method of the year by Summary: In this review, we provide a description of the existing and emerging technologies that can be used to capture spatially resolved gene and protein expression data from tissue. These technologies have provided new insight into the spatial heterogeneity of diseases, how reactions to disease are distributed within a tissue, which cells are affected, and molecular pathways that predict disease and response to therapy. Key Message: The upcoming years will see intense use of spatial transcriptomics technologies to better define the pathophysiology of kidney diseases and develop novel diagnostic tests to guide personalized treatments for patients.

Indexed as

Clinical translationGene expressionGlomerular diseasesKidney biopsyKidney pathologyPrecision medicineSpatial transcriptomics

Identifiers

PMID38600956
PMCPMC11006413

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.