ArticleClinical and molecular hepatology2024
Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment.
Article in Clinical and molecular hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- The Dynamic Nature of Renal Failure in Acute-on-Chronic Liver Failure: Sequence Matters.Gut and liver · 2026Article
- Rethinking ACLF prognosis: Can machine learning outperform conventional scores?: Editorial on "Predictive machine learning model in intensive care unit patients with acute-on-chronic liver failure and two or more organ failures".Clinical and molecular hepatology · 2026Article
- Acute-on-chronic liver failure: pathophysiological mechanisms and clinical management.Nature reviews. Gastroenterology & hepatology · 2026Review
- Outcomes of highly urgent living donor liver transplantation in Korean national data.Hepatobiliary surgery and nutrition · 2026Article
- Outcomes of Highly Urgent ABO-Incompatible Living Donor Liver Transplantation in National Databases.Journal of Korean medical science · 2026Article
- Oral Branched-Chain Amino Acids as a Cost-Effective Option for Managing Hepatic Encephalopathy.Yonsei medical journal · 2025Article
- Lipidomic analysis of alcohol use disorder patients revealed the biomarkers for alcohol-related liver disease susceptibility.Clinical and molecular hepatology · 2025Article
- Modified quick-SOFA score: Can it enhance prognostic assessment for hospitalized patients with chronic liver diseases?: Editorial on "Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment".Clinical and molecular hepatology · 2024Article
- Correspondence to editorial on "Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment".Clinical and molecular hepatology · 2024Article
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Abstract
BACKGROUND/
aimsQuick sequential organ failure assessment (qSOFA) is believed to identify patients at risk of poor outcomes in those with suspected infection. We aimed to evaluate the ability of modified qSOFA (m-qSOFA) to identify high-risk patients among those with acutely deteriorated chronic liver disease (CLD), especially those with acute-onchronic liver failure (ACLF).
methodsWe used data from both the Korean Acute-on-Chronic Liver Failure (KACLiF) and the Asian Pacific Association for the Study of the Liver ACLF Research Consortium (AARC) cohorts. qSOFA was modified by replacing the Glasgow Coma Scale with hepatic encephalopathy, and an m-qSOFA ≥2 was considered high.
resultsPatients with high m-qSOFA had a significantly lower 1-month transplant-free survival (TFS) in both cohorts and higher organ failure development in KACLiF than those with low m-qSOFA (Ps<0.05). Subgroup analysis by ACLF showed that patients with high m-qSOFA had lower TFS than those with low m-qSOFA. m-qSOFA was an independent prognostic factor (hazard ratios, HR=2.604, 95% confidence interval, CI 1.353-5.013, P=0.004 in KACLiF and HR=1.904, 95% CI 1.484- 2.442, P<0.001 in AARC). The patients with low m-qSOFA at baseline but high m-qSOFA on day 7 had a significantly lower 1-month TFS than those with high m-qSOFA at baseline but low m-qSOFA on day 7 (52.6% vs. 89.4%, P<0.001 in KACLiF and 26.9% vs. 61.5%, P<0.001 in AARC).
conclusionBaseline and dynamic changes in m-qSOFA may identify patients with a high risk of developing organ failure and short-term mortality among CLD patients with acute deterioration.
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