Evidence map›Paper›PMID 38600655›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Formation of Anisotropic Conducting Interlayer for High-Resolution Epidermal Electromyography Using Mixed-Conducting Particulate Composite.

Zifang Zhao, Han Yu, Duncan J Wisniewski, Claudia Cea, Liang Ma, Eric M Trautmann, Mark M Churchland, Jennifer N Gelinas, Dion Khodagholy

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. 3D printing of micro-nano devices and their applications.Microsystems & nanoengineering · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zifang ZhaoDepartment of Electrical Engineering, Columbia University, New York, 10027, USA.
Han YuDepartment of Electrical Engineering, Columbia University, New York, 10027, USA.
Duncan J WisniewskiDepartment of Electrical Engineering, Columbia University, New York, 10027, USA.
Claudia CeaDepartment of Electrical Engineering, Columbia University, New York, 10027, USA.
Liang MaDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Eric M TrautmannDepartment of Neuroscience, Columbia University, New York, NY, 10032, USA.
Mark M ChurchlandDepartment of Neuroscience, Columbia University, New York, NY, 10032, USA.
Jennifer N GelinasDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Dion KhodagholyDepartment of Electrical Engineering, Columbia University, New York, 10027, USA.ORCID 0000-0003-0805-4612

Funding

Closed-Loop Modulation of Hippocampal-Cortical Communication in Temporal Lobe EpilepsyR01NS118091 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Jennifer Gelinas · 2021 to 2026
$2.0M
Organic Closed-loop Electrochemical Array for Neurodevelopment (OCEAN)RF1NS128669 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KHODAGHOLY, DION · 2022 to 2022
$1.5M
Conformable, Expandable Neural Interface Device for the developing brainR21EY032381 · NEI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GELINAS, JENNIFER, KHODAGHOLY, DION · 2021 to 2022
$463k
National Science Foundation 1944415National Science Foundation 2219891NEI NIH HHS R21 EY032381NIH HHS R01NS118091NIH HHS R21 EY 32381-01NIH HHS RF1NS128669NINDS NIH HHS R01 NS118091NINDS NIH HHS RF1 NS128669
6 · The paper itself

Abstract

Epidermal electrophysiology is a non-invasive method used in research and clinical practices to study the electrical activity of the brain, heart, nerves, and muscles. However, electrode/tissue interlayer materials such as ionically conducting pastes can negatively affect recordings by introducing lateral electrode-to-electrode ionic crosstalk and reducing spatial resolution. To overcome this issue, biocompatible, anisotropic-conducting interlayer composites (ACI) that establish an electrically anisotropic interface with the skin are developed, enabling the application of dense cutaneous sensor arrays. High-density, conformable electrodes are also microfabricated that adhere to the ACI and follow the curvilinear surface of the skin. The results show that ACI significantly enhances the spatial resolution of epidermal electromyography (EMG) recording compared to conductive paste, permitting the acquisition of single muscle action potentials with distinct spatial profiles. The high-density EMG in developing mice, non-human primates, and humans is validated. Overall, high spatial-resolution epidermal electrophysiology enabled by ACI has the potential to advance clinical diagnostics of motor system disorders and enhance data quality for human-computer interface applications.

Indexed as

ElectromyographyAnimalsAnisotropyElectric ConductivityElectrodesEpidermisHumansMiceanisotropic conductorsconducting polymersEMGorganic bioelectronics

Identifiers

PMID38600655
PMCPMC11251554

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.